Treatment for CA Flashcards
MOA of aklylating agents in treatment of CA
- alkylate DNA (bind DNA) and inhibit replication
Name the 4 alkylating agents
- Mechlorethamine
- Cyclophosphamide
- Cisplatin
- Carmustin, Lomustine
how is Cyclophosphamide activated
cytochrome P-450
toxicity of Mechlorethamine
- vesicant: causes blistering
toxicity of Cyclophosphamide
- hemorrhagic cystitis
- treatment: MESNA
toxicity of Cisplatin
- acoustic nerve damage
important characteristic of Carmustine and Lomustine
highly lipid soluble; can get into brain
Name the three anti-metabolites
- Methotrexate (Methotrexate®)- also immunosuppressive
- 6-Mercaptopurine (Purinethol®)- metabolite of azathioprine
- 5-Fluorouracil (Adrucil®)
MOA: of methotrexate
- inhibits dihydrofolate reductase
What drug is given to decrease toxicity of methotrexate
Leucovorin
Methotrexate toxicity
- hepatotoxicity
MOA of antimetabolites
- inhibitis purine and pyrimidine synthesis
How is 6-Mercaptopurine metabolized
xanthine oxidase
Allopurinol has what effect on 6-Mercaptopurine
increases its toxicity
***Xanthine oxidase inhibitor
6-Mercaptopurine is a metabolite of what
- azathioprine
MOA of 5-Fluorouracil
- inhibits thymidylate synthase-blocks DNA synthesis
leucovorin (folinic acid) has what effect on 5-Fluorouracil
increases response by providing folate
Name the Abx used in the treatment of CA
- Doxorubicin Hydrochloride (Adriamycin®)
- Bleomycin Sulfate (Blenoxane®)
toxicity of Doxorubicin
- Cardiotoxic worse with iron
toxicity of Bleomycin
pulmonary fibrosis
List the three plant alkaloids
- Vinblastine Sulfate (Velban®)
- Vincristine Sulfate (Oncovin®)
- Paclitaxel (Taxol®)
MOA of Plant alkaloids
- bind to microtubules, mitosis inhibitors
toxicity of Vincristine
- peripheral neuropathy
toxicity of Vinblastine
- “blasts bone marrow” myelosuppression
