Treatment Flashcards
1
Q
Mechanism of action of Tamoxifen?
A
ER antagonist
2
Q
Risks of Tamoxifen ?
A
Been shown to increase risk of endometrial carcinoma
Increased risk of DVT
3
Q
Mechanism of action if Anastrazole and Letrozole
A
Aromatase inhibitors
Reduce the peripheral oestrogen synthesis
4
Q
How does Herceptin work ?
A
Immunotherapy which targets the HER2 receptors within the malignancy
Monoclonal antibody
5
Q
What Endocrine treatment is preferred in pre vs post menopausal women ?
A
Pre menopause = tamoxifen
Post menopause = Aromatase inhibitors
6
Q
Risks of Aromatase Inhibitors?
A
Only used post menopause
Increases risk of osteoporosis (may require bisphosphonates to prevent this)
7
Q
Types of surgical treatment ?
A
Wide local excision (WLE)
Mastectomy
