Treating hypertension Flashcards
Goal
BP below 140/90
Treatments
- Diuretics
- Sympatholytics
- Calcium channel blockers
Diuretics
ALL
Indirectly prevent the re-absorption of water in the kidneys and sodium
LOOP
Furosemide supplemented with spironolactone/amiloride
THIAZIDES
Bendrdoflumethiazide
POTASSIUM SPARING
Not acting directly on sodium channels
Furosemide site of action
Thick segment ascending limb of Henle’s loop
Thiazides site of action
Early distal convoluted tubule
Potassium sparing
Tubule and collecting duct distal nephron
Loop diuretic MOA
Inhibiting Na/K/Cl co-transporter
Thiazide diuretic MOA
Inhibit sodium-chloride in distal tubule
Potassium sparing diuretic MOA
Distal tubule Sodium channel inhibitor
Aldosterone receptor antagonist
Dihydropyridines (CCB)
Nifedipine
Amlodipine
Dihydropyridines mechanism
Block Ca2+ channels in arterioles
Hypertension
Dilation for peripheral vessels (lower BP)
Dilation of coronary arteries (increase blood flow)
Nifedipine & amlodipine reflex effect
Lower BP
Baroreceptor reflex
Stimulate medulla
Firing of SNS to Beta receptors in heart
Nifedipine reflex effects
Lacks direct cardiosupressant
Non-dihydropyridines (CCB)
Verapamil
Diltiazem
Non-dihydropyridines mechanisms
Hypertension
Act on heart to slow conduction