Treating hypertension Flashcards

1
Q

Goal

A

BP below 140/90

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2
Q

Treatments

A
  • Diuretics
  • Sympatholytics
  • Calcium channel blockers
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3
Q

Diuretics

A

ALL
Indirectly prevent the re-absorption of water in the kidneys and sodium

LOOP
Furosemide supplemented with spironolactone/amiloride

THIAZIDES
Bendrdoflumethiazide

POTASSIUM SPARING
Not acting directly on sodium channels

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4
Q

Furosemide site of action

A

Thick segment ascending limb of Henle’s loop

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5
Q

Thiazides site of action

A

Early distal convoluted tubule

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6
Q

Potassium sparing

A

Tubule and collecting duct distal nephron

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7
Q

Loop diuretic MOA

A

Inhibiting Na/K/Cl co-transporter

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8
Q

Thiazide diuretic MOA

A

Inhibit sodium-chloride in distal tubule

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9
Q

Potassium sparing diuretic MOA

A

Distal tubule Sodium channel inhibitor
Aldosterone receptor antagonist

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10
Q

Dihydropyridines (CCB)

A

Nifedipine
Amlodipine

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11
Q

Dihydropyridines mechanism

A

Block Ca2+ channels in arterioles
Hypertension
Dilation for peripheral vessels (lower BP)
Dilation of coronary arteries (increase blood flow)

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12
Q

Nifedipine & amlodipine reflex effect

A

Lower BP
Baroreceptor reflex
Stimulate medulla
Firing of SNS to Beta receptors in heart

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13
Q

Nifedipine reflex effects

A

Lacks direct cardiosupressant

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14
Q

Non-dihydropyridines (CCB)

A

Verapamil
Diltiazem

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15
Q

Non-dihydropyridines mechanisms

A

Hypertension
Act on heart to slow conduction

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16
Q

Verapamil

A

Blocks Calcium channels in arterioles heart
Dilation of peripheral vessels (Lowers BP)
Dilation of coronary arteries (Increases blood flow)
Blockade at SA node (Decrease heart rate)
Blockade at AV node (Decrease nodal conduction)
Blockade in myocardium (Decrease contractile force)

17
Q

Verapamil

A

Blocks Calcium channels in arterioles heart
Dilation of peripheral vessels (Lowers BP)
Dilation of coronary arteries (Increases blood flow)
Blockade at SA node (Decrease heart rate)
Blockade at AV node (Decrease nodal conduction)
Blockade in myocardium (Decrease contractile force)