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respiratory physio > transport of oxygen and co2 > Flashcards

transport of oxygen and co2 Flashcards

1
Q

CO2 production by cells

A

200ml/min

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2
Q

metabolic arteriovenous CO2 difference

A

40ml/L

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3
Q

metabolic arteriovenous O2 difference

A

50ml/L

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4
Q

O2 use by cells

A

250ml/mi

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5
Q

tissue pCO2

A

> 50

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6
Q

tissue PO2

A

> 10

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7
Q

hypoxic hypoxia

A

inadequate O2 uptake in lungs

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8
Q

stagnant (ischemic) hypoxia

A

inadequate blood flow to an organ (arteriosclerosis, PVD, stroke, MI)

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9
Q

anemic hypoxia

A

inadequate blood o2 carrying capacity. inactivated hemoglobin

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10
Q

histotoxic hypoxia

A

interference with mitochondrial respiration (like cyanide poisoning)

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11
Q

normal Hb

A

15g/dL

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12
Q

RBC carry ___ times more o2 than plasma

A

65

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13
Q

how many subunits does hb have

A

4

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14
Q

each gm of Hb can carry up to how much o2?

A

1.31ml

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15
Q

what shape is the Hbo2 curve

A

sigmoid

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16
Q

the ratio of o2 bound to hb compared to total amount that can be bound is

A

oxygen saturation

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17
Q

maximal amt of o2 bound to hb is

A

oxygen capacity

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18
Q

***what is the Hb P50 point

A

27!!!

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19
Q

what is your paO2 when the sat is 90

A

60

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20
Q

what is your paO2 when the sat is 50

A

27!

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21
Q

rough rule for sat to Pao2

A

40,50,60 for sat 70,80,90

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22
Q

the higher the affinity, the ___ the saturation

A

higher

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23
Q

the top of the curve represents

A

lungs

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24
Q

the middle of the curve represents

A

capillaries

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25
Q

the starting point of the curve represents

A

tissues

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26
Q

the x axis on curve

A

po2

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27
Q

the y axis

A

hb sat %

28
Q

carbon monoxide has ___ times the affinity for Hb than O2

A

250

29
Q

nitric oxide binds to Hb _____ times more strongly than o2

A

200000.

30
Q

what is NO used for

A

to treat pulmonary hypertension

31
Q

as PaO2 in the tissues decreases, the __ affinity Hb has for it, so…

A

less, so O2 is dumped in the tissues

32
Q

left =

A

love = lungs

33
Q

right =

A

release

34
Q

which way does alkalosis shift the curve

A

left

35
Q

which way does acidosis shift the curve

A

right

36
Q

which way does hyperthermia shift the curve

A

right

37
Q

which way does hypothermia shift the curve

A

left

38
Q

which way does increased 2,3, DIPG shift the curve

A

right

39
Q

which way does carboxyhemoglobin and methemoglobin shift the curve?

A

left

40
Q

which way does increased H+ shift the curve

A

right

41
Q

which way does increased pCO2 shift the curve

A

right

42
Q

Bohr effect

A

Hb releases more o2 in an acidic environment. an increase in H+ decreases the Hb’s affinityy for o2. its the cells way of asking hb to release o2 to support aerobic metabolism

43
Q

PRBC’s in the package shift the curve

A

left… because cold and less 2,3. dipg

44
Q

myoglobin has ___ affinity for O2, and this causes a shift to the ____

A

increased, left

45
Q

fetal blood causes a shift

A

left

46
Q

O2 content in blood is the sum of

A

carried on Hb and dissolved

47
Q

shift up is caused by

A

increased 02 capacity-

48
Q

shift down is caused by

A

decreased 02 capacity - anemia

49
Q

CO production in a resting adult

A

200ml/min. increases 6 fold with exercise.

50
Q

what are the 3 ways CO2 is transported by blood

A

as a gas dissolved directly in food, bicarb, ad bound to hb and plasma

51
Q

what is the MAIN way co2 is transported

A

HCO3 bicarb! 70%

52
Q

venous blood transports ___ CO2 than arterial blood

A

more

53
Q

haldane effect

A

upon binding o2, HB releases CO2 and H+ which in turn is converted to CO2. increased O2 causes the erythrocyte to release CO2. deoxygenated blood (venous) is able to carry more CO2

54
Q

shifting the curve ___ causes decreased o2 delivery to tissues

A

left

55
Q

the reaction that converts CO2 to HCO3 requires

A

the enzyme carbonic anhydrase

56
Q

mixed venous blood in pulm artery sat and pa02

A

75% paO2 40

57
Q

what binds irreversibly to hb

A

nitric oxide

58
Q

venous hb affinity shift

A

Po2 of 70 mmHg Shift to the right reducing the affinity for O2 below. shifting occurs bc of Bohr effect - an increase in H+ decreases hb’s affinity for o2. increases delivery of o2 to tissues

59
Q

Cao2 formula

A

(SO2 x hb x 1.31) + (Po2 x 0.003)

60
Q

DO2 (oxygen delivery)

A

caO2 x CO

61
Q

ability to bind with CO2 is ___ in deoxygenated hb

A

increased

62
Q

the presence of HB in normal arterial blood increase its oxygen concentration approx how many times?

A

70

63
Q

an increase in what increase 02 affinity of hb

A

carbon monoxide

64
Q

severe anemia with normal lugs, you’d expect

A

low oxygen concentration of mixed venous blood

65
Q

in carbon monoxide poisionig you’d expect

A

reduced oxygen concentration of mixed venous blood

respiratory physio (12 decks)

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