Transplants - tcell mediated

Question 1

Which has a higher survival rate?

Answer 1

Deceased donor organ - less; 10 years
Live organ donor - higher; 13-14 years

Question 2

Immune response to transplanted graft -what are the three phases

Answer 2

Phase 1 - recognition of foreign antigen
Phase 2 - Activation of antigen-specific lymphocytes
Phase 3 - Effector phase of graft rejection

Question 3

What are the main protein variations in clinical transplantation?

Answer 3

ABO
HLA

Answer 4

T cell mediated
B cell

Question 5

Why is it called HLA

Answer 5

Called HLA as they were first described on leukocytes

genes for MHC are on chromosome 6

Question 6

Where is HLA 1 found vs HLA 2 found?

Answer 6

HLA 1 - expressed on all cells; ABC
HLA 2 - on antigen presenting cells only; DR, DQ, DP

Question 7

What happens in T cell mediated rejection?

Answer 7

APC presents a peptide on a T cell and gets activated if they are foreign antigens

Answer 8

what do you mean by A B DR antigenic?

Answer 9

1 HLA mismatch
1 HLA-B mismatch
0 HLA-DR mismatch

Answer 10

Proliferation and activaiton of CD4+ helper and CD8+ cells

Release of IL2 and 15

Question 11

What do you measure to look out for graft rejection?

Answer 11

Tubular cells release creatinine

Tubulitis
You measure creatinine

Question 12

Drugs anti CD3

Answer 12

Anti-CD3 targets the T cell receptor activation?

Question 13

MTOR inhibitors

Answer 13

Target downstream of ?cytokines