Transplantation Reactions Flashcards
1
Q
Pre-existing recipient antibodies react to donor antigen and activate complement
A
Hyperacute
2
Q
Widespread thrombosis of graft vessels–>ischemia/necrosis
A
Hyperacute
3
Q
CD8+ T cells activated against donor MHC, or antibodies develop after transplant
A
Acute
4
Q
Vasculitis of graft vessels with dense interstitial lymphocytic infiltrate
A
Acute
5
Q
CD4+ cells respond to recipient APCs presenting donor peptides, including allogeneic MHC
A
Chronic
6
Q
Cytokines–>proliferation of VSM and parenchymal fibrosis, dominated by arteriosclerosis
A
Chronic
7
Q
Donor T cells attack proteins on host cells
A
GVHD
8
Q
Maculopapular rash, jaundice, diarrhea, hepatosplenomegaly
A
GVHD
