Transplantation Reactions Flashcards

1
Q

Pre-existing recipient antibodies react to donor antigen and activate complement

A

Hyperacute

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2
Q

Widespread thrombosis of graft vessels–>ischemia/necrosis

A

Hyperacute

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3
Q

CD8+ T cells activated against donor MHC, or antibodies develop after transplant

A

Acute

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4
Q

Vasculitis of graft vessels with dense interstitial lymphocytic infiltrate

A

Acute

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5
Q

CD4+ cells respond to recipient APCs presenting donor peptides, including allogeneic MHC

A

Chronic

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6
Q

Cytokines–>proliferation of VSM and parenchymal fibrosis, dominated by arteriosclerosis

A

Chronic

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7
Q

Donor T cells attack proteins on host cells

A

GVHD

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8
Q

Maculopapular rash, jaundice, diarrhea, hepatosplenomegaly

A

GVHD

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