Cytokine Cheat sheet Flashcards
Endothelial cells: activation
Hypothalamus: fever
Liver: synthesis of acute phase proteins
IL-1
Proliferation and differentiation of T cells
IL-2
B cell switching to IgE
Th2 differentiation
IL-4
Class switching to IgA
Growth and differentiation of eosinophils
IL-5
Hypothalamus: fever
Liver: synthesis of acute phase proteins
IL-6
B and T cell development
IL-7
Suppresses macrophage function
Decreases expression of MHC II and Th1
IL-10
Stimulates IFN-g production, increased cytotoxic activity
Induces differentiation of T cells into Th1 cells
IL-12
Induces cytokine, chemokine, and antimicrobial production
IL-17
Differentiation of B cells into plasma cells
IL-21
Activation of neutrophils and endothelial cells, fever, synthesis of acute phase proteins, apoptosis
TNF-a
All cells: anti-viral state, increased MHC I expression
NK cells: proliferation and activation
Type I interferons
Activation of macrophages, upregulation of MHC II, Th1 differentiation, B cells switching to IgG1 and IgG3
IFN-g
Inhibition of inflammation
TGF-B
