Brainscape's Knowledge GenomeTM


Top Flashcards (Certified)
All Flashcards

MLSCI 475 > Transplantation Immunology I > Flashcards

Transplantation Immunology I Flashcards

1
Q

Define Transplantation

A
  • act of transferring cells, tissues or organs from one site to another:
    — can be owned (autograft)
    — person to person (allograft)
    — animal to person (xenograft)
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Why do we perform kidney transplants for patients that can undergo hemodialysis ?

A
  • hemodialysis cost is expensive and continuous
  • survival rate for hemodialysis decreases with age
  • transplant improves quality of life
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Sources for Stem Cell Transplantation

A
  • bone marrow
  • peripheral blood
  • umbilical cord blood
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Transplantation antigens

A
  1. Major Histocompatibility Complex molecules (MHC) = Human Leukocyte Antigens (HLA)
    - cell surface proteins that present peptides to T cells
  2. ABO antigens
    - carbohydrates on RBC surface
    - produce naturally-occurring antibodies to non-self ABO antigens
  3. Minor Histocompatibility antigens
    - derived from polymorphic self-proteins
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Clinically relevant loci of MHC/ HLA

A

A
B
C
DR
DQ
DP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Antigens of MHC I

A

A
B
C

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Antigens of MHC II

A

DR
DQ
DP

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Diversity in HLA molecules

A

MHC are highly polymorphic and co-dominantly expresses maternal and paternal HLA
- lots of alleles

NOTE: polymorphism mainly in beta chain of MHC

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q
A
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

HLA Inheritance

A
  • Mendelian (haplotypes from father and mother)
  • Antigens are co-dominantly expressed (homozygous or heterozygous) = offspring will have 1 of 4 HLA combinations

NOTE: offspring have 25% chance of being an HLA match

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

T or F; HLA diversity is associated with evolutionary advantage

A

TRUE; HLA diversity is associated with evolutionary advantage
- BUT becomes a challenge in transplantation

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

Why isn’t every donor matched for HLA ?

A
  • due to HLA diversity = DIFFICULT to find a 0 mis-matched (MM) donor
  • demand for organs > supply
  • graft survival is possible WITHOUT matching using immunosuppressive drugs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What results in graft rejection ?

A
  • HLA antigens that differ between donor and recipient
    recognized by T cells and B cells
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

WIP Indirect pathway of T cell recognition of alloantigen

A

Direct:
- T cell and APC from patient donor antigen presented to recipient T cell

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

WIP Direct pathway of T cell recognition of alloantigen

A
  • donor APC presents donor HLA antigen to recipient T cell
  • unique to transplantation
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
17
Q

WIP Antigen recognition of B Cell

A
  • B cells/ antibody recognize
18
Q

HLA epitopes

MLSCI 475 (24 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2025 Bold Learning Solutions. Terms and Conditions