Transplantation Immunology

Question 1

CD28

Answer 1

• Expressed constituitively on T-Cells
• Binds with CD80

Question 2

Syngeneic Graft

Answer 2

• Genetically Identical
• Either Isograft or autograft

Question 3

Indirect Alloimmune recognition

Answer 3

Just peptide

Question 4

Time frame for acute graft rejection?

Answer 4

2-21 days

Question 5

Allogeneic Graft

Answer 5

• Allelic different graft
• Xeno or Allo graft

Question 6

Three Stages of Graft Acceptance?

Answer 6

1. Revascularization (d3-7)
2. Heal (d7-10)
3. Resolve (d12-14)

Question 7

Two stages of Second Set Rejection

Answer 7

1. Cellular infiltration (d2-4)
2. Thromob/Necro (d5-6)

Question 8

Four main immunosuppression agents

Answer 8

1. Steroids (Prednisone)
2. Adjunctive (Imuran,Cellcept,Rapamune)
3. Calcineurin Inhib (Cyclosporine,Tacrolimus)
4. Anti-lymphos(Campath,Thymoglogulin,Zenapax)

Want to avoid initial T-cell recognition; espeically IL-2

Question 9

Direct Alloimmune recognition

Answer 9

Just MHC

Question 10

Three stages of first set rejection

Answer 10

1. Revascularize (d3-7)
2. Inflamm (d7-10)
3. Thrombo/Necro (d12-14)

Question 11

CD40L

Answer 11

• Co-stim found on T-helpers
• Binds with CD40 on B-cells for G.C.s, Class-Switch and Delayed type hypersensitivity

Question 12

Four ways to deal with ab mediated reaction

Answer 12

1. Plasmapheresis
2. IV Ig
3. Rituximab (against CD20 on B-cells)
4. Bortezomib (block plasma ab production)

Question 13

Semi-Indirect Alloimmune recognition

Answer 13

MHC and Peptide recognition

Question 14

Tmeframe for Chronic graft rejection?

Answer 14

Around 3months

Question 15

CD80

Answer 15

• Gets upregulated in cells during inflammation
• Binds with T-cell’s CD28