Transplantation

Question 1

What is the major barrier to transplantation?

Answer 1

immune response (mostly T cells)

Question 2

what lymphocyte is involved in 1st and 2nd set rejection reactions?

Answer 2

T cells (mainly CD4+)

Question 3

This test is referred to as “microcytotoxicity” test

Answer 3

HLA serology typing

Question 4

What does HLA serology typing usually identify?

Answer 4

Class I HLA loci (HLA-A, B, C)

Question 5

Can traditional HLA typing identify Class II HLA alleles?

Answer 5

no, needs other testing techniques

Question 6

Why are HLA labs starting to use qPCR?

Answer 6

increased accuracy and speed

Question 7

This testing method has resulted in discovery of large number of “micropolymorphisms” in the human genome

Answer 7

HLA loci sequence-based testing

Question 8

How are HLA haplotypes usually inherited?

Answer 8

one allele from each parent. Rarely, you get one allele from one parent and a combination of both alleles from the other parent

Question 9

Polymorphic self-proteins that differ in amino acid sequences between individuals give rise to ____

Answer 9

minor histocompatibility antigens

Question 10

This immunosuppressant blocks calcineurin/calmodulin

Answer 10

Cyclosporin and FK506 (tacro)