T cell mediated diseases

Question 1

5 circumstances that lead to a T-Cell mediated disease

Answer 1

When they respond to an
1) autoantigen
2) persistent antigen
3) inappropriate antigen
4) transplant antigen
5) superantigen

Question 2

What initiates a T4 hypersensitivity reaction?

Answer 2

CD4+ Th1 cells

Question 3

What mediates a type 4 hs reaction?

Answer 3

macrophages

Question 4

2 phases of a Type 4 HS reaction

Answer 4

initiation and effector phases

Question 5

What occurs in the sensitization/initiation phase of a T4 HS reaction

Answer 5

An antigen presenting cell (macrophage or langerhans cell) presents something to a CD4+ Th cell. that T cell then differentiates into Th1 or CD8+ cells

Question 6

What is the target antigen of T1DM?

Answer 6

pancreatic beta-islet cells

Question 7

What is the target antigen of MS?

Answer 7

oligodendrocyte proteins

Question 8

Demyelinating disease, perivascular inflammation, paralysis, and ocular lesions are associated with which Type 4 hypersensitivity?

Answer 8

multiple sclerosis

Question 9

What is the target antigen of RA?

Answer 9

antigens in synovial membrane (possibly type 2 collagen)

Question 10

What is the target antigen of some peripheral neuropathies in a type 4 HS rxn?

Answer 10

schwann cell antigen

Question 11

What is the target antigen of hashimoto’s thyroiditis?

Answer 11

Thyroglobulin

Question 12

Hypothyroidism, hard goiter, and follicular thymitis are associated with which type 4 hypersensitivity?

Answer 12

Hashimoto’s thyroiditis

Question 13

What is the classic example of a superantigen?

Answer 13

Toxic Shock syndrome toxin (TSST1)