Autoimmunity

Question 1

This type of self-tolerance is a result of deletion or editing, acting at the thymus or bone marrow (T cells and B cells)

Answer 1

Central tolerance

Question 2

This type of self-tolerance results from a physical barrier preventing self-antigen access to lymphoid system and acts in peripheral organs

Answer 2

Antigen segregatioin

Question 3

This type of self-tolerance results from cellular inactivation from weak signaling without a co-stimulus, and takes place in secondary lymphoid tissue

Answer 3

Peripheral anergy

Question 4

What type of self-tolerance results from suppression by cytokines or other intercellular signals and takes place in secondary lymphoid tissues and sites of inflammation?

Answer 4

tolerance to Regulatory T cells

Question 5

What type of tolerance results from deletion of self-reactive transitional B cells, induction of anergy, and action of Treg cells?

Answer 5

peripheral tolerance

Question 6

Phenomenon where viruses and bacteria have antigenic components that are similar or identical to their host

Answer 6

molecular mimicry

Question 7

What’s a classic example of molecular mimicry?

Answer 7

Rheumatic fever

Question 8

What are some viruses and bacteria that can induce nonspecific polyclonal B cell activation?

Answer 8

some gram neg bacteria
Herpes simplex
CMV
EBV
HIV

Question 9

This type 2 hypersensitivity reaction results from deposition of immune complexes in basement membranes, especially in the glomerulus, activation of complement, and recruitment of inflammatory cells

Answer 9

Goodpasture’s Disease

Question 10

This type 2 hypersensitivity results from overactivation of TSH receptors in the absence of TSH

Answer 10

Grave’s disease

Question 11

This type 3 hypersensitivity reaction causes patients to produce autoantibodies against DNA, histones, erythrocytes, platelets, leukocytes, and clotting factors

Answer 11

SLE

Question 12

Type 1 diabetes involved which 3 mechanisms/cells?

Answer 12

CD4+ T cells, CD8+ T cells, and autoantibodies

Question 13

Autoantibodies against islet cells –> cell destruction by antibody-dependent cell-mediated cytotoxicity is associated with which type 4 hypersensitivity?

Answer 13

T1DM

Question 14

Patients with MS have ______ in their CSF that recognizes antigens derived from myelin and attach myelin sheath

Answer 14

activated and autoreactive T cells