Transplant Flashcards
which virus is associated with acute organ rejection?
CMV
which virus is associated with chronic organ rejection?
EBV
what is the histological finding in chronic organ rejection?
Neointimal hyperplasia of donor arterioles
Graft atrophy, atherosclerosis
is fibrosis a late or early event in chronic organ rejection?
Late
what is the histological finding in hyper acute organ rejection?
Thrombosis
what is the histological finding in acute organ rejection?
Cellular infiltrates and graft cell apoptosis
which immunoglobulin type mediates hyper acute organ rejection?
IgG
what type of hypersensitivity reaction is implicated in chronic rejection?
Type IV - T Cell
to which vessels are first type renal transplants anastomosed?
External iliac artery and vein
what is lower limb swelling typically a sign of over 2 weeks following renal transplantation?
Lymphocele
what is the cause urological complications following renal transplant?
Poor blood supply to the transplanted ureter
how do urological complications typically present post renal transplant?
Within 5 weeks, pain and swelling at graft site
what is the main clinical feature of renal artery thrombosis post renal transplantation?
Sudden cessation of urine output
when does renal artery thrombosis typically occur post transplant?
Early
how does renal vein thrombosis typically present post transplant?
Discomfort at graft site associated with loss of urine output
