Transplant

Question 1

main indications for transplant (>90%)

Answer 1

leukemia
MM
Hodgkin’s lymphoma or NHL

Question 2

when is allogeneic transplant preferred?

Answer 2

“stem cell” disorder: AML, ALL, CLL, CML, myelodysplasia
exceptions:
1. MM: autologous
2. Follicular NHL: allogenic
3. Aggressive lymphoma w/ no remission: allogenic for GVH effect

Question 3

GVHD - which organs are affected

Answer 3

skin - rash
liver - increased LFTs
GI tract - nausea/vomiting/diarrhea

Question 4

Reduced intensity allogeneic stem cell transplant

Answer 4

pts get minimal chemo - enough to suppress immune system to prevent donor cell rejection
Donor cells infused - donor cells do the work of rejecting the tumor - COOL