Transfusion

Question 1

universal RBC donor

Answer 1

O

Question 2

universal RBC recipient

Answer 2

AB

Question 3

forward typing

Answer 3

what are the pt’s antigens?

Question 4

reverse typing

Answer 4

what are the pts antibodies?

Question 5

leukoreduction

Answer 5

to get rid of CMV

redules febrile non-hemolytic transfusion rxns

Question 6

irradiation

Answer 6

inactivates donor T cells to prevent GVHD

Question 7

at what hgb level is transfusion indicated?

Answer 7

hgb <7

Question 8

plasma tranfusion

Answer 8

prophylactic to correct abnormal coag testing prior to procedure
tx: massive transfusion

Question 9

cryoprecipitate use

Answer 9

only really used for fibrinogen deficiency (DIC) b/c there are pharm options for other factors

Question 10

when is platelet transfusion indicated in stable non-bleeding pt?

Answer 10

plt <5K

Question 11

intermediate spin cross matching

Answer 11

the final check for ABO compatibility

pt plasma + donor cells. agglutination = NOT compatible

Question 12

Anti-globulin cross match

Answer 12

the final check for compatibility with non-ABO antibodies

Question 13

most common cause of death due to transfusion

Answer 13

TRALI

Question 14

most common cause of TRALI

Answer 14

donor antibodies against HLA antigens

Question 15

acute hemolytic transfusion rxn

Answer 15

incompatible ABO or donor plama, non-ABO mediated, non-immune hemolysis
sx: fever/chills, vomiting, impeding doom

Question 16

hypersensitivity from transfusion

Answer 16

mild allergic

anaphylaxis (IgA hypersensitivity)

Question 17

TRALI

Answer 17

presence of donor antibodies against HLA antigens

sx: fever, ARDs, pulmonary infiltrates - 6 hrs after transfusion

Question 18

risk of any complication from transfusion

Answer 18

3-3.5%