translocations Flashcards
1
Q
t(15;17)
A
AML, specifically Acute promyelocytic leukemia subtype
17 - retinoic acid alpha receptor
15 - promyelocytic leukemia gene
p/w pancytopenia, DIC, Auer Rods
tx all-trans retinoic acid
2
Q
t(8;14)
A
Burkitt lymphoma
c-myc activation
round nuclei with basophilic cytoplasm containing prominent lipid vacuoles
3
Q
t(9;22)
A
CML, 30-60 yo
bcr-abl hybrid
leukocytosis with many myelocytes (immature myeloid cells)
4
Q
t(12;21)
A
ALL,
5
Q
t(14,18)
A
follicular lymphoma
bcl-2 activation
malignant cells with notches or clefts (centrocytes)
6
Q
t(11;14)
A
Mantle cell lymphoma
cyclin D1 activation
7
Q
t(11;22)
A
Ewing’s sarcoma
EWS gene on 22 joined to FLI1 gene on 11
