Translocations

Question 1

9:22

Answer 1

Philadelphia chromosome, CML Bcr-Abl over expression. P210KD tyrosine Kinase

Question 2

11:14

Answer 2

Mantle cell lymphoma (Bcl-1 gene [aka cyclin D])

Question 3

11:22

Answer 3

Degeorges

Question 4

12:21

Answer 4

ALL (better prognosis)

Question 5

14:18

Answer 5

Follicular NHL (Bcl-2)

Question 6

15:17

Answer 6

AML M3 (Auer Rods)

Question 7

8:14

Answer 7

Burkitts lymphoma (c-myc gene over expression)