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Transfusion Science III > Transfusion Science III - Blood Components Pt. 1 > Flashcards

Transfusion Science III - Blood Components Pt. 1 Flashcards

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1
Q

What are the four components that derive from donated blood?

A
  1. Resuspended Red Cells
  2. Fresh Frozen Plasma
  3. Platelets
  4. Fractionated Proteins
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2
Q

Describe the whole blood process to produce Fresh Frozen Plasma and Resuspended Red cells

A
  1. Whole blood rests at room temperature for 2 hours
  2. Whole blood filtered through leucodepletion to remove >5 million white cells per unit
  3. Platelets removed
  4. Blood centrifuged to separate plasma from red cells
  5. Plasma separated into another bag
    6.Plasma is frozen at minus 30 within 8 hours
  6. Separated red cells suspended in SAGM
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3
Q

Why must plasma be frozen 8 Hours after whole blood collection?

A

Avoid loss of coagulation factors

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4
Q

Why are males only allowed to donate plasma?

A

To avoid Transfusion Related Acute Lung Injury

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5
Q

why is leucodepletion done to whole blood?

A

1.Reduce risk of sepsis in a transfused patient
2.Remove cytomegalovirus from white blood cells to reduce risk of disease in immunocompromised patient
3. Reduce febrile non-haemolytic transfusion reaction

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6
Q

How many years is fresh frozen plasma stored.

A
  1. 2 years
  2. Once thawed, 4 hours at room temperature or 5 days at 4 degrees
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7
Q

What patients are Fresh Frozen Plasma given to?

A
  1. Disseminated Intravascular Coagulation
  2. Liver Disease
  3. Congenital factor deficiencies
    4.Thrombotic Thrombocytopenic purpura
  4. Haemolytic Uraemic syndrome
  5. Massic transfusion Protocol
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8
Q

How are cryoprecipitate produced?

A

Thawing of FFP forms cryoprecipitate containing factors VIII,XIII fibrinogen and fibronectin

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9
Q

What is the shelf life of stored cryoprecipitate and once it is thawed?

A

1.Frozen: 1 year at -30
2. Thawed: 4 hours at room temperature

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10
Q

Who is cryoprecipitate given to?

A
  1. Thrombotic Thrombocytopenic purpura
  2. Bleeding due to uraemia
  3. Massive Transfusion Protocol
  4. Congenital Bleeding Disorders
    a. Fibrinogen Factor I Deficiency
    b. Haemophilia A (Factor VII) Deficiency
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11
Q

Why are red cells suspended in SAGM?

A

Fed and Buffered against pH drop

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12
Q

What is SAGM composed of?

A
  1. Citric acid
  2. Sodium Citrate
  3. Sodium chloride
  4. Sodium phosphate
  5. dextrose
  6. adenine
  7. mannitol
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13
Q

How long and at what temperature is resuspended red cells stored at?

A
  1. 4 degrees minus or plus 2
  2. Stored up to 35 days
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14
Q

What patients receive resuspended red cells?

A
  1. Blood loss or anaemia to increase tissue oxygenation
  2. Massive transfusion protocol
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15
Q

What are the three other red cell components?

A
  1. Paediatric packs
  2. Washed red cells
  3. Frozen red cells
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16
Q

What are the three components of Paediatric packs?

A
  1. Red cell resuspended neonatal (0.5 - 0.7)
  2. Whole Blood plasma reduced (0.45 - 0.55)
  3. CRCIUT (0.75 - 0.9)
17
Q

Describe preparation of Washed Red Cells

A
  1. Red cells washed to remove plasma protein to 0.5 g or less
18
Q

What is the shelf life and storage temperature of washed red cells?

A
  1. Storage 4 degrees plus or minus 2
  2. Shelf life: 24 hours
19
Q

Who received washed red cells?

A
  1. IgA deficiency
20
Q

Describe the preparation of cryoprotectant

A
  1. red cells frozen in cryoprotectant
  2. stored at minus 80 in freezer or minus 190 in liquid nitrogen
21
Q

What happens to frozen red cells when they need to be used?

A
  1. Thawede and cryoprotectant removed via washing
  2. used within 24 hours of washing and thawing
22
Q

Who are frozen red cells given to?

A
  1. rare blood group individuals
23
Q

What are frozen red cells given cryoprotectants?

A

Prevent dehydration and injury from ice crystals

24
Q

What cryoprotectants are used in frozen red cells?

A
  1. Glycerol
  2. Dimethlsulphoxide
  3. Glucose and polyvinylpyrrolidone

Transfusion Science III (10 decks)

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