Transfusion Medicine Flashcards

1
Q

Cryoprecipitate components

A
  • factor 8, fibrinogen, vWF

- used in DIC for fibrinogen

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Acute hemolytic transfusion reaction

A
  • caused by ABO incompatibility
  • findings: fever, chills, flank pain, abd pain, dyspnea, hypotension, tachycardia, free hgb in plasma. Coombs test is positive
  • stop transfusion and notify blood bank
  • maintain urine output at all costs
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

Delayed hemolytic transfusion reaction

A
  • delayed emergence of alloantibodies that causes rapid extravascular clearance of transfused erythrocytes 1-3 days after transfusion.
  • findings: unexplained drop in hgb concentration, elevated serum bilirubin and LDH levels, increased retic count, decreased haptoglobin, presence of new alloantibody
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

Post-transfusion purpura

A
  • associated with thrombocytopenia >1 wk after transfusion
  • reaction is most common in women who become sensitized to HPA-1a after pregnancy or an earlier transfusion. Subsequent transfusion may then cause immune-mediated thrombocytopenia
  • diagnosis: antibodies to HPA-1a
  • treat: IV Ig
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Febrile nonhemolytic transfusion reaction

A
  • occurs at end of or after a transfusion and is caused by donor leukocyte cytokines or recipient alloantibodies directed against donor leukocytes
  • treatment: stop transfusion, antipyretic agents and steroids are given
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Uses of FFP

A

-used to replace coagulation factors

How well did you know this?
1
Not at all
2
3
4
5
Perfectly