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ISBB > Transfusion > Flashcards

Transfusion Flashcards

1
Q

Symptomatic anemia

A

<7g/dl

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2
Q

Thrombocyte count when platelet concentrate should be administered

A

Less than 50,000/uL

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3
Q

1 unit of whole blood or packed RBC can increase hematocrit by___

A

3% hematocrit or

1.0-1.5 g/dL hemoglobin

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4
Q

Storage time of CP2D

A

21 days

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5
Q

Additive solution content

A

Saline
Adenine
Glucose
Mannitol

SAGM /MAGS

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6
Q

Purpose of Mannitol in additive solutions

A

Stabilizing agent

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7
Q

Content of Rejuvenating Solutions

A

PIGPA OR PIPA

Phosphate
Inosine
Glucose
Pyruvate
Adenine
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8
Q

light spin speed

End product

A

3200 xg for 2-3 mins
Or
2000 xg for 3 minutes

Product: platelet Rich Plasma
Temp: 22 deg Celsius

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9
Q

Heavy spin speed
End product
Temperature

A 
5000 xg for 5 minutes
Or 
3600 RPM for 5 minutes
Platelet poor plasma
4 deg Celsius
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10
Q

Platelet concentrate should contain at least _____

And ph

A

5.5 x 10 ^10 platelets

pH: greater than or equal to 6.2

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11
Q

Agitation of platelets purpose

A

Prevent aggregation and to promote gas exchange

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12
Q

How many units can platelet concentrate be pooled

A

6-8

6-10 (Turgeon)

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13
Q

How many mL of plasma should be left after removal of platelets

A

50 mL

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14
Q

One RDP unit should increase px platelet count by

A

5,000 to 10,000 uL

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15
Q

One SDP can increase px platelet count by

A

30,000 to 60,000/uL

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16
Q

SDP unit should contain at least

A

3.0 x 10 ^11 platelets per unit

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17
Q

Failure to yield an increase in recipient’a platelet count leas than 5,000/uL

A

Platelet refractoriness

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18
Q

Cryoprecipitate contains (factors)

A 
Factor VIII
Factor XIII
vWF Factor
Fibrinogen
Fibronectin
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19
Q

Cryoprecipitate + Thrombin =

A

Fibrin glue

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20
Q

How many mL of plasma removed in preparation of cryoprecipitate

A

10-15 mL

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21
Q

Method used to irradiate blood components

A

Cesium ^137 source

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22
Q

WBC products aka

And examples

A

BRMs - biologic response modifiers

Cytokines and complement fragments

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23
Q

2 methods to reduce leukocytes

A

Pre-storage leuko-reduction

  • removed prior storage
  • prevent febrile transfusion caused by both WBCs and BRMs

Post-storage leuko-reduction

  • removed prior to issuing the unit
  • can prevent febrile transfusion by WBCs but not by BRMs (BRMs have accumulated during storage)
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24
Q

Removal and storage of blood work or blood components before an elective procedure for reinfusion during or after the procedure

A

Preoperative Collection

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25
Q

Blood collected before a surgical procedure and simultaneously replaces a comparable volume of crystalloid or colloid solution

A

Acute Normovolemic Hemodilution

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26
Q

Collection and reinfusion of blood lost by a px during surgery
Device that utilize vacuum used to collect shed blood

A

Intraoperative Collection

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27
Q

Blood is collected from a drainage tube placed at the surgical site
Used microaggregate filter to screen our debris

A

Postoperative Collection

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28
Q

General requirements for autologous donation

A

Age (no requirements)
Hb (11g/dl)
Hct (33%)
3 day intervals (3 day before surgery)

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29
Q

Most common anticoagulant for apheresis

A

Acid Citrate Dextrose (ACD)

30
Q

Platelet count of donor for plateletpheresis

A

150 x10^3/uL

31
Q

Requirements for erythracytopheresis
Male
Female

A

Male 5’1” 130 lbs hct 40%

Female 5’5” 150 lbs hct 40%

32
Q

Mendel’s Law
First
Second
Third

A

First Law: Law of Segregation
Second Law: Law of Independent Assortment
Third Law: Law of Dominance

33
Q

Only blood group antigen that has been shown to be sex-linked

A

Xg

34
Q

Mathematical formula that explains Mendelian Inheritance

A

Hardy-Weinberg Principle

p+ q = 1
p^2 + 2pq + q^2 = 1

35
Q

Trisomy 18

A

Edward’s Syndrome

36
Q

Trisomy 13

A

Patau Syndrome

37
Q

Anti-A1 Lectin

A

Dolichos biflorus

38
Q

Anti-B Lectin

A

Griffonia (Bandeiraea) simplicifolia

39
Q

Anti-H lectin

A

Ulex europaeus

40
Q

Greatest amount of H Ag to Lowest amount of H ag

A

O > A2 > B > A2B > A1 > A1B

41
Q

similar to Bombay except that there is normal ABH expression in secretions and body fluids

A

Para-Bombay phenotype

Genes: hh, Se

42
Q

What microorganism associated with acquired B phenomenon

A

Proteus vulgaris (sometimes E.coli)

43
Q

Bacterial enzyme associated with acquired B

A

Deacetylase

44
Q

Treatment for RBCs with acquired B phenomenon

A

Acetic Anhydride

45
Q

ISBT # of Rh

A

004

46
Q

Immunogenicity of Rh antigens

A

D > c > E > C > e

47
Q

Individuals do not possess the genes needed to synthesize Cc or Ee

A

D Deletion (D- -)

48
Q

Antigen expressed when both c and e in the cis position or located in the same haplotype

A

f (ce)

49
Q

Who developed Hybridoma technology

A

Kohler and Milstein

50
Q

Antibody associated with Paroxysmal Cold Hemoglobinuria and demonstrated by Donath Landsteiner test

A

Autoanti-P

51
Q

Second rated to D in terms of immunogenicity

A

Kell Ag

52
Q

What phenotype has

  • an X linked inheritance
  • rbcs are acanthocytic in nature
  • wbcs are def of NADH-oxidase enzyme
  • associated with CGD
  • rbcs lack Kx and Km
A

McLeod phenotype

53
Q

Confers to resistance against Plasmodium vivax infections

A

Duffy null phenotype (anti-Fy3)

54
Q

Disappear rapidly both in vivo and in vitro thats why they are notoriously known for association with DHTR

  • demonstrate dosage
  • resist lysis in 2M Urea
A

Kidd Antibodies

55
Q

Can produce mixed field agglutination

A

Anti-Lua

56
Q

Incomplete antibody best demonstrated in AHG phase

A

Anti-Lub

57
Q

Time for centrifugation in serofuge

A

20 seconds

58
Q

Presence of two cell populations in a single individual

A

Chimerism

True chimerism (twins)
Mosaicism (dispermy) - two sperm cells fertilized one egg
59
Q

Gel Card centrifugation time

A

10 minutes

60
Q 
Sulfhydryl agents (2)
And purpose
A

2-mercaptoethanol (2-ME)
Dithiothreitol (DTT)

  • destroys pentameric structure of agglutinating IgM
61
Q

Lectins is to plants as

Prolectin is to

A

Snails

62
Q

Specific gravity of copper sulfate hemoglobin determination and equivalent hemoglobin

Time for reading

A

1.053 (12.5 g/dL)

15 seconds

63
Q

How many times blood bank is inspected each year

A

Once per year

64
Q

Temperature of storage of antisera

A

2-6 deg Celsius

65
Q

Indications of Exchange Transfusion

A

0.5 mg/dl/hr rise in bilirubin or

Rise of 10 mg/dl in the first 24 hours

66
Q

Intrauterine transfusion is done by (2)

A

Intraperitineally

Cordocentesis

67
Q

Indications of Intrauterine transfusion

A
  • amniotic fluid A450 results are in high zone II or zone III
  • hb level < 10g/dl
  • fetal hydrops on ultrasound examination
68
Q

Post thaw storage of FFP

A

1-6 deg C, transfuses within 24 hours

69
Q

Purpose of plastic bag in thawing FFP

A

Prevent water contamination of the entry port

70
Q

Examples of crystalloid

A

Ringer’s lactate solution

7.5% normal saline

ISBB (3 decks)

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