Transfusion

Question 1

Clinical Response of 1u PRBC transfusion

Answer 1

Inc Hgb 10 mg/dL

Inc Hct 3%

Question 2

Clinical response if 1u of Platelets (50-70ml)

Answer 2

Inc Plt 5000-10,000

Question 3

Clinical response of 1u FFP transfusion (200-250ml)

Answer 3

Inc coag factors 2%

Question 4

Hgb content level to maintain adequate oxygenation in a normovolemic patient without comorbids

Answer 4

70 g/L

100 g/L if with physiologic compromise

Question 5

Threshold for prophylactic platelet transfusion

Answer 5

10,000/uL

Question 6

Platelet transfusion target level for invasive procedures

Answer 6

50,000/uL

Question 7

Contents of FFP

Answer 7

Fibrinogen
Antithrombin
Albumin
Protein C and S

Question 8

Contents of Cryoprecipitate

Answer 8

Fibrinogen
Factor VIII
von Willebrand Factor (vWF)

Question 9

Occurs when recipient has preformed antibodies that lyse donor erythrocytes

Answer 9

Immune-mediated hemolysis

ABO isoagglutinins in majority

Question 10

Lab evaluation for hemolysis

Answer 10

serum haptoglobin
LDH
indirect bilirubin

Question 11

Most frequent reaction associated with transfusion if cellular blood components

Answer 11

Febrile Nonhemolytic transfusion reaction (FNHTR)

Question 12

Causes urticarial reactions from transfusion

Answer 12

Plasma proteins

Question 13

Clinical manifestations of transfusion-associated Graft-Versus-Host-Disease (mediated by T lymphocytes)

Answer 13

Fever + Cutaneous eruption + Diarrhea + Liver Function abnormalities + Marrow aplasia + Pancytopenia

Question 14

Most common cause of transfusion-related fatalities

Answer 14

Transfusion-related Acute Lung Injury (TRALI)

Question 15

Usually results from transfusion of donor plasma that contains high-titer anti-HLA class II antibodies that bind to receptor leukocytes

Answer 15

TRALI

Question 16

Reaction presenting as thrombocytopenia 7-10 days after platelet transfusion (predominantly in women)

Answer 16

Posttransfusion Purpura

Question 17

Dyspnea + PO2 at room air <90% + bilateral infiltrates on CXR + Systolic HPN + Inc BNP

Answer 17

Transfusion-associated circulatory overload (TACO)

Question 18

Iron content in 1 unit of PRBC

Answer 18

200-250 mg

Question 19

Level in which SSx of Iron Overload become evident

Answer 19

100units of RBC (20g)

Question 20

Drug associated with transfusion hypotension

Answer 20

ACE inhibitors