IDA and Hypoproliferative Anemias

Question 1

Principal Iron Regulatory Hormone

Answer 1

Hepcidin

Question 2

Transferrin with highest affinity for receptors

Answer 2

Differic Transferrin (compared to monoferric)

Question 3

MC form of hypoproliferative anemia

Answer 3

Iron Deficiency Anemia

Question 4

Major role of Iron

Answer 4

Carry O2 as part of Hgb

Question 5

Amount of iron to replace senescent RBCs

Answer 5

20mg/day

Question 6

Amount of iron needed to replace losses

Answer 6

Males: 1mg elemental iron/day

Females: 1.4mg elemental iron/day
increased requirements during last 2 trimesters in pregnancy: 5-6mg/day

Question 7

Stages of IDA

Answer 7

1. Negative Iron Balance
2. Iron-deficient Erythropoeisis
3. IDA

Question 8

PE findings of advanced tissue Fe deficiency

Answer 8

Cheilosis

Koilonychia

Question 9

Most convenient lab test to estimate iron stores

Answer 9

Serum Ferritin Level

Question 10

DDx for Hypochromic, Microcytic Anemia

Answer 10

IDA
Thalassemia
Anemia of Inflammation
Myelodysplastic Syndromes (least common)

Question 11

Virtually diagnostic of absent body iron stores

Answer 11

Serum Ferritin <15ug/L

Question 12

Enhances oral iron absorption

Answer 12

Ascorbic Acid

Question 13

May inhibit oral iron absorption

Answer 13

Food intake (iron should be taken on an empty stomach)

Question 14

Mechanism of Anemia of Chronic Disease

Answer 14

Inadequate iron DELIVERY to the marrow despite presence of normal or increased iron stores

Question 15

Distinguishes IDA from Anemia of Inflammation

Answer 15

Serum Ferritin Levels

Question 16

Hemoglobin goal in hypoproliferative anemias

Answer 16

7-8 mg/dL (if without Cardiopulmonary compromise)

11 mg/dL (if with physiologic compromise)