Transdiagnostic approach Flashcards
What is a transdiagnostic approach?
The transdiagnostic approach focuses on identifying the common and core maladaptive temperamental, psychological, cognitive, emotional, interpersonal and behavioural processes that underpin a broad array of diagnostic presentations
Simply = Identifying a mechanism which is present across disorders
What does ‘Transdiagnostic’ mean?
‘Transdiagnostic’ simply means ‘across diagnoses’
The term transdiagnostic was first applied (quite narrowly) to …..?
Cognitive therapy across eating disorders (e.g anorexia and bulimia)
True or False?
Nowadays a ‘full’ transdiagnostic approach applies to all mental health diagnoses not just various categories
True
What is the evidence for the transdiagnostic approach? List the 4 questions researchers ask when conducting a transdiagnostic approach
1) Are symptoms shared across disorders?
2) Are underlying mechanisms shared across disorders?
3) Is there a unified theory applicable across disorders?
4) Is there a single treatment applicable across disorders?
True or False?
Individuals with particular diagnoses might not have elevated rates of symptoms not related to their diagnosis
False
Individuals with particular diagnoses might have elevated rates of symptoms not related to their diagnosis
Post-traumatic stress disorder symptoms are present in ……. disorders
Personality
There are elevated rates of depression and anxiety in….? List 3 disorders
1) Psychotic disorders (Birchwood et al., 2000),
2) Eating disorders (Bulik et al., 1997)
3) Substance abuse disorders (Merikangase et al., 1998)
True or False?
There are decreased rates of psychotic symptoms in people with anxiety and depression when compared with a non-clinical sample
False
There are elevated rates of psychotic symptoms in people with anxiety and depression when compared with a non-clinical sample
Although individuals are diagnosed with one category, they score very high on symptom clusters related to other/individual categories in the classification system
What does this suggest?
These symptoms are more on a spectrum than being separate from each other
True or False?
The majority of people have not/do not meet the criteria for more than one disorder diagnosis
False
The majority of people have/meet the criteria for more than one disorder diagnosis
Kessler et al. (2005) more than …..% of people diagnosed with a disorder in a given year, meet the criteria for multiple disorders
50%
Who suggested that more than 50% of people diagnosed with a disorder in a given year, meet the criteria for multiple disorders?
Kessler et al. (2005)
Depending on the study, …..% - …….% of individuals with one disorder have another disorder that they qualify for
32% - 80%
Individuals with one disorder have another disorder that they qualify for
This is known as…?
(High Levels of) Comorbidity
There is a significant proportion of people whose diagnosis shifts/changes
This is known as…?
Instability of Diagnosis
Barca-Garcia et al. (2007) followed up 10,000 patients at ten-time points:
Only …..% of specific personality disorders were stable over time
……% of cases of schizophrenia were stable
Only 29% of specific personality disorders were stable over time
70% of cases of schizophrenia were stable
True or False?
There is a significant proportion of people whose diagnosis shifts/changes
True
People shift in their diagnosis over time
When does this mostly happen?
Early in life
Often the case with childhood disorders where is hard to pin down a specific diagnostic category
Why do people shift in their diagnosis mainly early on in life?
Because often the case with childhood disorders, it is hard to pin down a specific diagnostic category
Who followed up with 10,000 patients at ten-time points in life to investigate the stability of diagnosis?
Barca-Garcia et al. (2007)
Who conducted a birth cohort study in New Zealand that used over 1000 participants (assessed every 2 to 6 years)?
Caspi et al., 2013
Caspi et al., 2013 conducted a birth cohort study in New Zealand that used over 1000 participants, and assessed every…..?
2 to 6 years
What did Caspi et al. examine in their study?
They examined the structure of psychopathology, taking into account dimensionality, persistence, co-occurrence, and sequential comorbidity of mental disorders across 20 years, from adolescence to midlife
They assessed diagnostic symptoms for a wide range of disorders
Caspi et al. used factor analysis in their study. What was this for?
To explore inter-correlations between symptoms
What evidence did Caspi et al find in their study?
They found evidence pointing to one general underlying dimension that summarized individuals’ propensity to develop any and all forms of common psychopathologies.
Caspi et al. found evidence pointing to one general underlying dimension that summarized individuals’ propensity to develop any and all forms of common psychopathologies.
They called this the…?
P factor
What is the P factor?
One general underlying dimension that summarized individuals’ propensity to develop any and all forms of common psychopathologies
What does the p factor correlate with? List 3
1) Great life impairment
2) Great childhood maltreatment
3) Poorer brain function in early life (the higher the p score- the more impairment)
The higher the p score, the …… impairment
More
What does the p factor explain about finding causes and treatments for individual mental disorders?
The p factor explains why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders
The p factor explains why it is challenging to find causes, consequences, biomarkers, and treatments with specificity to individual mental disorders.
How can this be improved?
Conducting transdiagnostic approaches
What factors might be transdiagnostic? List 3
1) Biological
2) Social
3) Brain circuitry
What are biological factors?
Genetic factors
What are social factors?
Shared interpersonal factors/expressed emotion (such as hostility & criticism in family members)
What are brain circuitry factors?
Structure of the brain and functional patterns of the brain (assessing areas of the brain that are active and differentiate people with mental health difficulties)
Why might biological factors be transdiagnostic?
Many disorders have shared genetic factors/vulnerabilities, e.g. schizophrenia, bipolar disorder, ADHD & major depression
Why might social factors be transdiagnostic?
Predicts relapse in bipolar disorder, schizophrenia, anxiety, depression and others
Why might brain circuitry be transdiagnostic?
Structurally: Goodkind et al., 2015 study – in 15,892 patients they found that grey matter loss converged across diagnoses in 3 regions
Functional patterns: assessing areas of the brain that are active and differentiate people with mental health difficulties; they found overlapping areas across disorders – this led research councils to look at this more transdiagnostically- the human connectome
What did Goodkind et al find regarding the grey matter/brain structure of people with disorders?
Grey matter loss converged across diagnoses in 3 regions
When assessing areas of the brain that are active and differentiate people with mental health difficulties, what did researchers find?
They found overlapping areas across disorders
When assessing areas of the brain that are active and differentiate people with mental health difficulties, researchers found overlapping areas across disorders
What did this lead to?
This led research councils to look at this more transdiagnostically- the human connectome
Which research groups conducted the analysis of the brain circuitry involved in psychopathology?
Buckholtz & Meyer-Lidenberg, 2012
Goschke, 2014
What did research groups conducting analysis of the brain circuitry involved in psychopathology identify?
They identified 4 different brain circuits with different brain functions involved in psychopathology
There are 4 different brain circuits with different brain functions involved in psychopathology.
List the 4 brain circuits
- Frontal-parietal
- Default mode network (the way the brain is functioning at rest)
- Corticolimbic (amygdala)
- Frontal-striatal
What is the function of the frontal-parietal brain circuit in psychopathology?
Working memory & performance monitoring
What is the function of the default mode network (the way the brain is functioning at rest) brain circuit in psychopathology?
Theory of mind & perspective taking