Transcription/Translation Flashcards
Inhibits initiation of transcription
High Mucosal penetrating AB
Can use alone for N. men
Red Urine/Contacts
Rifampin
Rifamycin
30S and 50S subunits for _____
70S = prokaryotes
40S and 60S subunits for ____
80S = eukaryotes
50S Inhibitor
Chloramphenicol
Clarithromycin
Clindamycin (+toxin inhibitor)
Azithromycin
C3 A
50S Inhibitor + Toxin Inhibitor
Clindamycin
Crosses BBB, may cause aplastic anemia due to mito depression
Gram - bacteria
Rarely used
Chloramphenicol
Used in penicillin allergic patients
Most often used AB
Erythromycin
Erythromycin includes–
Azithromycin
Clarithomycin
May allow growth of C diff and then pseudomembranous enterocolitis
Clindamycin
Aminoglycosides include:
Gentamicin
Amikacin
Kanamycin
Tobramycin
Use Aminoglycosides on:
Gram -
Aminoglycosides are:
and may cause:
thus require:
broad spectrum
ototoxic and nephrotoxic
hospitalization
30S Inhibitors
Gentamicin Amikacin Kanamycin Tobramycin Tetracycline Doxycycline
May cause upset stomach-30S inhibitor
Tetracycline
May cause dark teeth in infants, and impaired bone development, binds Ca
Tetracycline
Bacteriostatic 30S Inhibitors
Tetra/Doxycycline
Topical treatment for Impetigo
Used in nose for staph/strep
Muprocin
Inhibits Isoleucine tRNA
Muprocin
Treats MRSA, but high resistance
Linezolid (oxazolidinone)
Removes LPS from clone proteins
Binds Lipid A
Toxic
Polymyxin B
Membrane disruption–MRSA
Daptomycin
Block folic acid metabolism
Broad spectrum (aerobes and facultative)
Pneumo. carinii
Anaerobe resistant
Sulfonamides
Trimethoprim
Antimycobacterials used for
How many?
TB
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