Tranlocations, Characteristics, Immunophenotypes

Question 1

t(8:21)

Answer 1

AML

RUN-RUN

Question 2

inv(16:16)

Answer 2

Acute Myelomonocytic Leukemia

CBFB-MYH11

Question 3

t(15;17)

Answer 3

Acute Promyelocytic Leukemia

PML-RARA

Question 4

t(9;22)

Answer 4

BCL-ABR

Seen in CML and ALL

CML= good prognosis
B-cell ALL = bad prognosis

Question 5

1(11;19)

Answer 5

B-cell ALL

MLL rearrangement

Poor prognosis

Question 6

t(12;21)

Answer 6

B-cell ALL

Good prognosis

Question 7

Name the 4 potential Etiologies of CLL/SLL and designate a good or bad prognosis.

Answer 7

Del 13 - good
Trisomy 12
Del 11
Del 17p - bad

Question 8

What are the 2 cell markers that indicate somatic hypermutation in CLL memory B’s? What does that mean for the prognosis?

Answer 8

Zap-70

CD38+

Bad prognosis

Question 9

t(11;14)

Answer 9

Mantle Cell Lymphoma

Question 10

Popcorn cell

Answer 10

Nodular Lymphocyte Dominant Hodgkin Lymphoma

Question 11

Cyclin D1 overexpression

Positive Ki67 stain

Answer 11

Mantle Cell Lymphoma

Question 12

Smudge cells

Answer 12

CLL

Question 13

Single Auer rods

Answer 13

AML Run-Run t(8;21)

Question 14

Piles of Auer Rods

Answer 14

APL RARA t(15;17)

Question 15

c-KIT mutation

Tryptase Positive immunophenotype

Answer 15

Mastocytosis

Question 16

Positive Reticulin stain in the bone marrow

Answer 16

Primary Myelofibrosis

Question 17

Decreased EPO, but increased RBC count/HCT

Answer 17

Polycythemia Vera

Question 18

Main symptom = erythromyalgia

Treatment = hydroxyurea

Answer 18

Essential Thrombocythemia

Question 19

You can’t do an allogenic stem cell transplant for these 2 diseases.

Answer 19

Aplastic anemia and myelodysplasia.

The stem cells are already messed up.

Question 20

This cancer has a bimodal age distribution.

Answer 20

B-cell ALL

t(9;22)

Question 21

This form of ALL is most common in infants <1 yr.

Answer 21

t(11;19) MLL

Question 22

Only leukemia without lymphadenopathy.

TRAP stain, fried egg marrow

Answer 22

Hairy Cell Leukemia

Question 23

A kid comes in with a mediastinal mass on his X-ray, fever, anemia, and thrombocytopenia. You automatically think…..

Answer 23

T-cell ALL

Question 24

R-S Cells

Answer 24

Hodgkins Lymphoma

Question 25

t(14;18)

Answer 25

Follicular B-cell Lymphoma

Question 26

+ Bcl-2 stain IN THE GERMINAL CENTER

Answer 26

Follicular B-cell Lymphoma

Question 27

Overexpressed c-MYC due to EBV.

Answer 27

Burkitt’s Lymphoma

Question 28

How do you tell if a T cell proliferation is neoplastic rather than reactive?

Answer 28

Test for TCR clonality

Question 29

Expanded paracortex of Lymph node and random baby blood vessels interspersed.

Answer 29

Angio-immunoblastic T-cell Lymphoma

Question 30

Looks like psoriasis, but has Scezary cells floating in the bloodstream

Answer 30

Mycosis Fungiodes

Question 31

What cell does Mycosis Fungiodes infect?

Answer 31

CD4 T’s

Question 32

Congenital Version of Aplastic anemia is called….

Answer 32

Fanconi’s

Question 33

Main cause if aplastic anemia

Answer 33

Autoimmune destruction of Hematopoeitic stem cells

Question 34

Key lab finding in aplastic anemia

Answer 34

Decreased retic count with hypo cellular marrow

Question 35

Rouleaux

Answer 35

Multiple Myeloma

Question 36

IgM M-spike with no CRAB+, but hyperviscosity

Answer 36

Waldenstrom’s Macroglobulinemia

Question 37

Apple-green birefringence and congo red stain

Answer 37

Amyloidosis

Question 38

What receptor on osteoclasts do antibodies bind to cause bone lytic lesions?

Answer 38

RANK - activates them