Drug Names From Hell

Question 1

What drug do you give to counteract hyperuricemia? (excess uric acid seen in tumor cell breakdown)

Answer 1

Allopurinol

Question 2

What drugs do you give a Hemophiliac? MOA’s?

Answer 2

Desmopressin - causes release of vWF and Factor VIII from Weibel-Pallade Bodies

Aminocaproic Acid - Plasmin inhibitor (allows clots to form)

Question 3

How do you treat older people with AML?

Answer 3

Symptom reduction - they are too old and fragile to handle stem cell transplant

Question 4

Treatment for Polycythemia Vera.

Answer 4

Venesection/Phlebotomy

Question 5

Treatment for Essential Thrombocythemia.

Answer 5

Hydroxyurea (decrease platelets by increasing action of adenylate cyclase… increases cAMP levels)

Aspirin (irreversible platelet inhibitor)

Question 6

What treatment do you give people with Primary Myelofibrosis, whether they have the Jak-2 mutation or not?

Answer 6

Jak-2 inhibitors

It causes the MASSIVE splenomegaly to tone down.

Question 7

What drugs have been proven to provide the best outcome for multiple myeloma?

Answer 7

IMiDs.
Thalidomide
Lanilidomide

THEN GIVE AUTOLOGOUS SCT