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Heme > Hematologic Anti-cancer Drugs > Flashcards

Hematologic Anti-cancer Drugs Flashcards

1
Q

What does ATRA stand for and treat?

A

ATRA = All-Trans Retinoic Acid.

Treats ALL with PML-RARA translocation.

Acute Promyelocytic Leukemia

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2
Q

What does ATRA stand for and treat?

A

ATRA = All-Trans Retinoic Acid.

Treats ALL with PML-RARA translocation.

Acute Promyelocytic Leukemia

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3
Q

MOA of ATRA

A

Degrades the PML-RARA fusion protein, allowing differentiation of the promyelocytes.

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4
Q

Main drug to treat AML?

A

Cytarabine

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5
Q

MOA of Cytarabine

A

Bioactivated to Ara-CTP in the body and blocks DNA Polymerase

Prevents cell division

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6
Q

Main treatment for CML. MOA?

A

Imatinib - TKI inhibitor

Blocks the BCR-ABL fusion protein from binding and constitutively activating the TK.

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7
Q

CLL is treated with what?

A

Chronic Lymphocytic Leukemia is treated with FLUDARABINE

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8
Q

MOA of fludarabine

A

Bio-activated in the cell, produces DNA strand termination.

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9
Q

Non-Hodgkins Lymphoma treatment.

A

CHOP

Cyclophosphamide
Vincristine
Doxorubicin
Prednisone

sometimes with Rtuximab. Then it’s called R-CHOP

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10
Q

MOA aspariginase.

A

Blocks synthesis of asparagine, therefore protein synthesis.

Pegaspargase (Asparagus rides the pegasus) –> treats ALL

ALL is a children’s’ disease and you hear about Pegasus as a child, and don’t want to eat asparagus.

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11
Q

What do you treat Ph+ ALL with?

A

Ph+ means it has the BCR-ABL fusion protein variant. Treat it with Imatinib and chemo.

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12
Q

MOA cyclophosphamide

A

Alkylating agent - alkylates the N-7 guanine in DNA and causes x-linking

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13
Q

MOA Daunorubicin, Doxorubicin, Idarubicin. Toxicity?

A

DNA intercalators, Topo II inhibitors, and Free radical generators

Cardiotoxicity. Left sided heart failure

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14
Q

MOA of Prednisone.

A

Corticosteroids block NfKB from translocating to the nucleus. Proliferation inhibitors.

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15
Q

MOA of Dacarbazine

A

Bio-activated DNA methylator

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16
Q

MOA of Interferon

A

Direct anti proliferative effect.

Activates CTLs and NK cells, and Macrophages.

17
Q

What cancer do you use Interferon to treat?

A

Hairy Cell Leukemia

18
Q

What’s the only anti-cancer drug you can take and still breast feed?

A

Rituximab. CD20+ b cell monoclonal antibody.

19
Q

What drugs are associated with paternal teratogenicity?

A 
Cyclophosphamide
Doxorubicin
Methotrexate
Epirubicin
Interferon -alpha
20
Q

MOA of ATRA

A

Degrades the PML-RARA fusion protein, allowing differentiation of the promyelocytes.

21
Q

Main drug to treat AML?

A

Cytarabine

22
Q

MOA of Cytarabine

A

Bioactivated to Ara-CTP in the body and blocks DNA Polymerase

Prevents cell division

23
Q

Main treatment for CML. MOA?

A

Imatinib - TKI inhibitor

Blocks the BCR-ABL fusion protein from binding and constitutively activating the TK.

24
Q

CLL is treated with what?

A

Chronic Lymphocytic Leukemia is treated with FLUDARABINE

25
Q

MOA of fludarabine

A

Bio-activated in the cell, produces DNA strand termination.

26
Q

Non-Hodgkins Lymphoma treatment.

A

CHOP

Cyclophosphamide
Vincristine
Doxorubicin
Prednisone

sometimes with Rtuximab. Then it’s called R-CHOP

27
Q

MOA aspariginase.

A

Blocks synthesis of asparagine, therefore protein synthesis.

Pegaspargase (Asparagus rides the pegasus) –> treats ALL

ALL is a children’s’ disease and you hear about Pegasus as a child, and don’t want to eat asparagus.

28
Q

What do you treat Ph+ ALL with?

A

Ph+ means it has the BCR-ABL fusion protein variant. Treat it with Imatinib and chemo.

29
Q

MOA cyclophosphamide

A

Alkylating agent - alkylates the N-7 guanine in DNA and causes x-linking

30
Q

MOA Daunorubicin, Doxorubicin, Idarubicin. Toxicity?

A

DNA intercalators, Topo II inhibitors, and Free radical generators

Cardiotoxicity. Left sided heart failure

31
Q

MOA of Prednisone.

A

Corticosteroids block NfKB from translocating to the nucleus. Proliferation inhibitors.

32
Q

MOA of Dacarbazine

A

Bio-activated DNA methylator

33
Q

MOA of Interferon

A

Direct anti proliferative effect.

Activates CTLs and NK cells, and Macrophages.

34
Q

What cancer do you use Interferon to treat?

A

Hairy Cell Leukemia

35
Q

What’s the only anti-cancer drug you can take and still breast feed?

A

Rituximab. CD20+ b cell monoclonal antibody.

36
Q

What drugs are associated with paternal teratogenicity?

A 
Cyclophosphamide
Doxorubicin
Methotrexate
Epirubicin
Interferon -alpha

Heme (9 decks)

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