Hematologic Anti-cancer Drugs Flashcards
What does ATRA stand for and treat?
ATRA = All-Trans Retinoic Acid.
Treats ALL with PML-RARA translocation.
Acute Promyelocytic Leukemia
What does ATRA stand for and treat?
ATRA = All-Trans Retinoic Acid.
Treats ALL with PML-RARA translocation.
Acute Promyelocytic Leukemia
MOA of ATRA
Degrades the PML-RARA fusion protein, allowing differentiation of the promyelocytes.
Main drug to treat AML?
Cytarabine
MOA of Cytarabine
Bioactivated to Ara-CTP in the body and blocks DNA Polymerase
Prevents cell division
Main treatment for CML. MOA?
Imatinib - TKI inhibitor
Blocks the BCR-ABL fusion protein from binding and constitutively activating the TK.
CLL is treated with what?
Chronic Lymphocytic Leukemia is treated with FLUDARABINE
MOA of fludarabine
Bio-activated in the cell, produces DNA strand termination.
Non-Hodgkins Lymphoma treatment.
CHOP
Cyclophosphamide
Vincristine
Doxorubicin
Prednisone
sometimes with Rtuximab. Then it’s called R-CHOP
MOA aspariginase.
Blocks synthesis of asparagine, therefore protein synthesis.
Pegaspargase (Asparagus rides the pegasus) –> treats ALL
ALL is a children’s’ disease and you hear about Pegasus as a child, and don’t want to eat asparagus.
What do you treat Ph+ ALL with?
Ph+ means it has the BCR-ABL fusion protein variant. Treat it with Imatinib and chemo.
MOA cyclophosphamide
Alkylating agent - alkylates the N-7 guanine in DNA and causes x-linking
MOA Daunorubicin, Doxorubicin, Idarubicin. Toxicity?
DNA intercalators, Topo II inhibitors, and Free radical generators
Cardiotoxicity. Left sided heart failure
MOA of Prednisone.
Corticosteroids block NfKB from translocating to the nucleus. Proliferation inhibitors.
MOA of Dacarbazine
Bio-activated DNA methylator
MOA of Interferon
Direct anti proliferative effect.
Activates CTLs and NK cells, and Macrophages.
What cancer do you use Interferon to treat?
Hairy Cell Leukemia
What’s the only anti-cancer drug you can take and still breast feed?
Rituximab. CD20+ b cell monoclonal antibody.
What drugs are associated with paternal teratogenicity?
Cyclophosphamide Doxorubicin Methotrexate Epirubicin Interferon -alpha
MOA of ATRA
Degrades the PML-RARA fusion protein, allowing differentiation of the promyelocytes.
Main drug to treat AML?
Cytarabine
MOA of Cytarabine
Bioactivated to Ara-CTP in the body and blocks DNA Polymerase
Prevents cell division
Main treatment for CML. MOA?
Imatinib - TKI inhibitor
Blocks the BCR-ABL fusion protein from binding and constitutively activating the TK.
CLL is treated with what?
Chronic Lymphocytic Leukemia is treated with FLUDARABINE
