Tranexamic Acid (TXA)

Question 1

Tranexamic Acid Class

Answer 1

Hemostatic agent, Antifibrinolytic agent, plasminogen inhibitor

Question 2

Tranexamic Acid Mechanism of Action

Answer 2

Inhibits the activation of plasminogen, Clotting factors and circulating platelet plugs can form a seal and reduce bleeding

Question 3

Tranexamic Acid Indications

Answer 3

Blunt or penetrating trauma less than 3 hours from onset with hemodynamic compromise, bleeding

Question 4

Tranexamic Acid Contraindications

Answer 4

MOA more than 3 hours prior to EMA care, Subuarachnoid hemorrhage

Question 5

Tranexamic Acid Dosage and Administration

Answer 5

1 g IV infusion over 10 min