Diltiazem Flashcards

1
Q

Diltiazem Class

A
  • Calcium channel blocker
  • Antidysrhythmic
  • Antianginal
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2
Q

Diltiazem Mechanism of Action

A
  • Inhibits extracellular calcium ion influx across membranes of myocardial cells and vascular smooth muscle cells
  • No effect on serum calcium concentrations
  • Substantial inhibitory effects on the cardiac conduction system
  • Less-negative inotropic effects than verapamil
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3
Q

Diltiazem Indications

A
  • Stable narrow QRS tachycardia
  • To control the ventricular rate in patients with AF or atrial flutter without preexcitation
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4
Q

Diltiazem Containdications

A
  • Hypotension
  • Cardiogenic shock
  • Wide-complex tachycardia
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5
Q

Diltiazem Dosage and Administration

A

Initial dose: 15 - 20 mg (0.25 mg/kg) IV/IO slowly over 2 min
After 15 min, a second bolus of 20 to 25 mg (0.35 mg/kg) IV/IO can be given slowly over 2 min
Patients older than 65 require a max initial dose of 10 mg IV/IO and second dose of 20 mg IV/IO
Maintenance infusion: 5 - 15 mg/h titrated to a physiologically appropriate heart rate

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