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OChem II > Tramadol > Flashcards

Tramadol Flashcards

1
Q

Tramadol AKA in the US

A

Ultram

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2
Q

How does Tramadol function as a painkiller?

A

Tramadol inhibits reuptake of serotonin and norepinephrine which boosts mood and consequently dulls perception of pain.

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3
Q

Tramadol was developed in what year? In which country?

A

1962
Germany

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4
Q

Which enzyme in the liver demethylates Tramadol?

A

Cytochrome P450
(CYP2D6)

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5
Q

What is the demethylated form of Tramadol called and why is it important?

A

O-desmethyltramadol

Has an affinity 200x stronger than straight tramadol for the receptors mu-opioid receptors.

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6
Q

Fluoxetine AKA

A

Prozac

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7
Q

Fluoxetine Use

A

Antidepressant

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8
Q

Tramadol + Antidepressant Interaction Side Effect

A

Seizures

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9
Q

MAOI

A

Monoamine Oxidase Inhibitors

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10
Q

Describe How Tramadol can be Synthesized

A

Nucleophilic attack of a Grignard or RLi species upon a carbonyl group.

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11
Q

What plant can synthesize Tramadol

A

African Peach AKA Pin Cushion Tree

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OChem II (9 decks)

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