Training Pharmacist

Question 1

What drugs need a dose decrease when smoking is discontinued?

Answer 1

Theophylline
Cinacalcet
Ropinirole
Antipsychotic (clozapine, olanzapine, chlorpromazine HCL, haloperidol)

Question 2

What is used next like in treatment of osteoporosis if bisphosphonate is CI

Answer 2

Refer for specialist treatment with;
- zoledronic acid
- strontium ranelate
- raloxifene
- denosumab
- teriparatide

Question 3

What drugs need the dose clearly defined?

Answer 3

Schedule 2 and 3 drugs

Question 4

What is chromaturia?

Answer 4

Side effect of idebenone used for visual impairment

Metabolites of the drug may cause red-brown discolouration of urine

Question 5

What anticoagulant is given SC after abdominal surgery for prophylaxis of VTE

Answer 5

Fondaparinux

Question 6

What is used to treat constipation that hasn’t responded to laxatives from different classes and have had constipation for at least 12 months?

Answer 6

Linaclotide

Question 7

What is used to assess cardiovascular risk for patients

Answer 7

QRISK2 - preferred
JBS3

Question 8

What is used to manage diarrhoea associated with Crohn’s disease?

Answer 8

Loperamide hydrochloride
Codeine phosphate
Colestryramine

Question 9

What is the target plasma concentration of theophylline?

Answer 9

10-20 mg/L (55-110 micromol/L)

Question 10

What are the symptoms of theophylline toxicity?

Answer 10

Tachycardia
Hypokalaemia

Question 11

When is plasma theophylline concentration measured?

Answer 11

• 5 days after starting oral treatment
• At least 3 days after any dose adjustment

Take sample 4-6 hours after an oral dose of MR tab