Respiratory Flashcards
Adult management of asthma
SABA
- Step 1: low dose ICS - preventer therapy
- Step 2: Add LABA - normally as a combination inhaler
- Step 3: Add LTRA - leukotriene receptor antagonist
- Step 4: High dose ICS, add fourth drug; SR theophylline / LTRA
- Step 5: Oral steroid
Examples of LTRA
Montelukast
Zafirlukast
How often should asthma treatment be reviewed?
Every 3 months
What is in a MART?
A single inhaler containing;
- low maintenance ICS
- fast acting LABA
Main side effect of SABA
Hypokalaemia
When to step up SABA
- if using inhaler at least 3 times a week
- night time symptoms
- asthma attack requiring systemic steroids in last 2 years
Main side effect of ICS
Oral thrush
rinse mouth with water after dose
What ICS brands are not interchangeable
Beclomethasone
Qvar and Clenil Modulite
Main side effect of theophylline
Hypokalaemia
Maintain same brand
What are the three parts in step 3 treatment of asthma
- Part 1 (no response): STOP LABA - increase ICS
- Part 2 (inadequate control) : CONTINUE LABA - increase to medium dose ICS
- Part 3 (inadequate control): CONTINUE LABA - trial LTRA, LAMA or SR theophylline
How should oral prednisolone be given?
Single dose in the morning to prevent insomnia
What LABAs are used in asthma
Formoterol - BD
Salmeterol - BD
When wouldn’t LABA be initiated?
Rapidly deteriorating asthma
What LABA can be used as relievers in addition to regular use as preventer in asthma
Formoterol
Inhaler brands containing LABA
And which type
- Fostair - beclomethasone + Formoterol
- Symbicort - Budesonide + Formoterol
- Duoresp spiromax - budesonide + Formoterol
- Seretide - Fluticasone + Salmeterol
Side effects of LABA
- hand tremors, tachycardia, hypERGlycaemia
- hypOKalaemia
- serious cardiovascular events (QT prolongation)
Dose frequency of ICS
exception?
Twice daily
Except Ciclesonide - OD
Mometasone - OD/BD
Age restriction of ICS inhalers
Easyhaler - 18+
QVAR - 12+
Side effects of ICS
Hoarse voice
Sore throat
Oral thrush - use daktarin gel (miconazole)
Paradixical bronchospasm - STOP and give alternative
In mild bronchospasm; use SABA beforehand or transfer from pMDI to dry powder inhaler
What inhaler must be kept refrigerated
Fostair
Side effects of LRA
- Churg Strauss syndrome (vasculitic rash, worsening pulmonary symptoms, cardiac complications)
- Liver toxicity
Target plasma conc of theophylline
10-20 mg/L
take sample after 4-6 hours
Signs of theophylline toxicity
’FAST and SICK
- vomiting and GI effects initially
- tachycardia, CNS stimulation
- arrhythmias, convulsions and hypOKalaemia
Theophylline interactions
- HypOKalaemia - diuretics, corticosteroids, B2 agonists
- Convulsions - Ciprofloxacin, quinolones
- CCB, cimetidine, phenytoin, fluconazole, Macrolides - Enzyme inhibitors
- St John’s Wort, Rifampicin