Trachte

Question 1

Alpha 1 receptor

Answer 1

• found on smooth muscle of blood vessels
• medaites contraction to increase BP
• phenylephrine is agonist

Question 2

Alpha 2 receptor

Answer 2

• found in medulla, the GI and platelets
• inhibits NE release –> DECREASES BP
• examples are clonidine, guanfacine, alpha methyldopa, and tizanidine

Question 3

B1 receptor

Answer 3

• acts on cardiac tissue
• increases contractility –> increased BP
• dobutamine is agonist

Question 4

Beta 2 Receptor

Answer 4

• found on blood vessels and lungs
• relaxes smooth muscle through vasodilation
• decreases BP
• ex. metaproterenol, albuterol, terbutaline, ritodrine, salmeterol

Question 5

Isoproterenol

Answer 5

• acts via B1 (heart, increase BP) and B2 receptors
• affects radius via B2 more strongly –> decreases BP
• comt metabolism
• parenteral or aerosol

Question 6

Dobutamine

Answer 6

• acts via Beta 1 receptor
• increases BP
• positive inotrope (increases HR and SV)

Question 7

Norepinephrine

Answer 7

• acts on alpha 1 receptor
  
  • vasoconstricts –> increases BP
• acts on beta 1 receptor
  
  • ​increases contractility –> increases BP

Question 8

Epinephrine

Answer 8

• acts on alpha1
  
  • vasoconstricts –> increases BP
  • works as topical hemostat
• acts on beta 2
  
  • vasodilates –> decreases BP
  • use to restore heart beat

Question 9

Indirect sympathomimetics that release NE from nerve

Answer 9

• Inhibits axoplasmic pump
  
  • cocaine, imipramine, nicotine
• Reverses axoplasmic pump
  
  • amphetamine, ephedrine, sudafed