Trace minerals and Fat Sol Vits Flashcards
Zinc function
metalloenzymes need zinc:
- dna synthesis
- realease vit A from stores
- free radicle protection
- immune function
- RBC sythesis
- growth and development
RDA for men and women for Zinc
UL?
Men= 11mg
Women = 8mg
40mg/d
Should you supplement zinc?
No! why?
Ul is 40mg/d and if this exceeds zinc toxicity will occur ( nausea, vommiting, diarrhea)
and interference with copper metabolism ( altered iron function, reduced immunity, increased intentional metallothionen)
Where is zinc stored in the intestinal cells?
in metallothionein which is a sulfur rich protein that binds week with metals. If body needs zinc metallothionien releases zinc to albumin and transferrin which take it to the rest of the body. if body doesn’t need zinc than it is excreted in shed intestinal cells
Zinc enhancers
acids and amino acids
Zinc inhibitors
phytate oxalate polyphenols insoluable fiber folate H2 blockers
Absorbtion rate of zinc
15-40%
depends on absorption efficiency. when low dietary intake absorption increases and pancreas recycling to small intestine increases. when high intake, endogenous fecal losses increase.
Zinc deficiency
hard to diagnose,
GI infections, compromised growth , poor appetite low immune system and CNS disfunction
Widespread in developing countries
Thyroxin- thyroid hormones T3 and T4
iodine is essential for making thyroid hormones:
metabolic rate of every cell
body temp
RBC synthesis
Growth and reproduction and brain development
RDA abd UL for iodine
150ug
average intake is 8g
UL= 1100ug
what is cretinism
poor brain development if iodine deficient when pregnent
describe iodine deficiency and how it relates to to an enlarged loiter compared to when iodine levels are sufficient
low T3 and t4 the hypothalamus stimulates the pituitary to release TSH which goes to the thyroid gland and tells it to produce more T3 and T4 however T3 and T4 need iodine so if low iodine than enlarged thyroid ( goiter ) occurs. Enlarges to try and trap as much iodine as possible
high iron affects?
overload of iron occupies all the transferrin binding sites which decrease Zn absorption
high zinc affects?
high zinc means high metallothionein which means copper is more strongly bond and not released from mucusal cells
low protein affects zinc how?
low protein means low albumin and that means low zinc released from mucosal cells