Anemias Flashcards
hepcidin
hormone that regulates iron balance
microcytic and hypochromic
smaller and pale RBC
caused by iron deficiency anemia
megablastic and pernicious
caused by folate or vit B12 deficiency
LARGE RBC
hemosiderin
another type of iron storage protein like ferritin, but hemosiderin releases iron more slowly than ferritin
the liver turns ferritin into hemosiderin when iron levels are high so as to prevent free radical iron in blood
transferrin
iron transport protein , delivers iron to muscles and bone marrow
ferritin
iron storage protein that capture iron from food and stores it in small intestine, if body is in need iron it will release it to transferrin, if body doesn’t need it iron will get secreted with the intestinal cells (3-5 days)
heme iron vs non heme iron
heme is better absorbed and can only come from animal flesh
non heme can come from both animal and plant sources
MFP factor
in meat fish and poultry and it is a peptide that promotes the absorption of noontime iron in meals eaten at the same time
% iron absorbed in vegetarian diet
10, 18 in normal diet
does iron get recycled after RBC die after 4 months
yes you only lose about 0.5-1.0 mg a day
erythropoiesis
making of blood cells
third stage of iron deficiency results in deficient erythropoiesis
total body iron
2.5-3.8 g in RBC
RDA for iron men and women
men 8mg/d
women 18mg/d
33mg/d if vegan
27 if pregnent
hemosiderosis
overload of hemosiderins
hemochromatosis
iron overload
genetic disorder caused by defective hemocidin ( hormone that regulates iron balance ) and can be fatal
