trace: iron

Question 1

the majority of iron in the body is found in ____ (65%)

Answer 1

hemoglobin

Question 2

HEME iron is found in animal products like ___ and ___, and is part of ____

Answer 2

beef
fish
hemoglobin

Question 3

NONHEME iron is found in __ and ___ and is reduced in the ___

Answer 3

plants
supplements
SI

Question 4

HEME iron is absorbed via ___ ___ using ____

• more is absorbed
• Fe rel’d by HEME OXYGENASE

Answer 4

facilitated diffusion

HCP1 (heme carrier prot)

Question 5

NONHEME iron is absorbed via ___ ___ using ___

Answer 5

facilitated diffusion

DMT (divalent min transp)

Question 6

NONHEME iron is DIGESTED by _____, which requires vit __

Answer 6

ferrireductase

C

Question 7

NONHEME iron is transported out of enterocyte across membrane by ____, which uses Cu

Answer 7

ferroportin

Question 8

Fe is extremely reactive so it must be always bound to a protein; when it is transported in blood/plasma it utilizes ___

Answer 8

transferrin

Question 9

if not required immediately, Fe will bind to _____, which is synth’d in both the SI and liver

Answer 9

ferritin

Question 10

Fe is made into hemoglobin and myoglobin or bound to ferritin for storage in these three locations

Answer 10

spleen
liver
bone marrow

Question 11

when iron stores are LOW, there is a higher presence of ____, while when they are HIGH, there is a higher concentration of ____, to keep it stored

Answer 11

transferrin

ferritin

Question 12

iron RDA is __ mg/day for men and __ mg/day for women, and is found in seafood, lean meat, legumes etc

Answer 12

8

18

Question 13

five demographics most at risk for iron deficiency, the mc nutritional def in the US:

Answer 13

kids (6 mo-1 yr)
boys 10-19
women 10-44
pregnant
runners (m) and athletes (f)

Question 14

three symptoms of iron def

Answer 14

fatigue
pallor
decreased immunity
(impaired activation of vit D)

Question 15

taking iron supplements can cause a ___ def, while ___ can cause in iron def

Answer 15

zinc

copper

Question 16

iron toxicity (via supplements) can cause ______ (GENETIC inability to properly metab it), which causes organ damage

Answer 16

hemochromatosis

Question 17

tiny RBC lacking color seen in iron def anemia is called:

Answer 17

hypochromic hypercytic anemia

Question 18

iron functions to syth heme, transport ___ (as part of heme), and as part of _____

Answer 18

O2

cytochrome (catalase)

Question 19

class of enzymes req for digestion of heme iron prior to absorp

Answer 19

oxidoreductase

Question 20

___, found in spinach and chocolate, can decrease iron absorp

Answer 20

oxalate

Question 21

blood protein that is elevated in a patient presenting with iron def

Answer 21

transferrin