Toxicology Exam II Crossword Key

Question 1

PCP uncouples oxidative phosphorylation and blocks or decreases this:

Answer 1

ATP

Question 2

This organ is primarily responsible for removing excess copper from the bloodstream:

Answer 2

Liver

Question 3

A high rumen pH favors the nonionized state of this, enhancing systemic absorption:

Answer 3

Ammonia

Question 4

T/F: Florida, California, Oregon and Nevada have soil rich in molybdenum

Answer 4

True

Question 5

Metaldehyde toxicity typically causes CNS __________

Answer 5

Excitation

Question 6

You can increase renal excretion of 2,4-D by __________ the urine pH

Answer 6

increasing

Question 7

This chelating agent is similar but more hydrophilic than dimercaprol (BAL):

Answer 7

Succimer

Question 8

A potential source of exposure for PCP is __________ treated with it, which may be licked by the animal

Answer 8

wood

Question 9

Causes lipid peroxidation and free radicals in iron toxicity:

Answer 9

Free iron

Question 10

Animal group most susceptible to inorganic arsenical toxicity:

Answer 10

Herbivores

Question 11

Specific chelator for iron:

Answer 11

Deferoxamine

Question 12

High sodium levels in the brain lead to __________ because of the action of osmosis

Answer 12

edema

Question 13

‘Blackberry Jam’ spleen is associated with what toxin?

Answer 13

copper

Question 14

This toxin is bound to transferrin in the blood:

Answer 14

iron

Question 15

Both fomepizole and ethanol are __________ inhibitors of alcohol dehydrogenase

Answer 15

competitive

Question 16

Depigmentation of the hair around this area can be a sign of molybdenum toxicosis:

Answer 16

eyes

Question 17

Paraquat can be measured in __________ up to 48 hours post-exposure

Answer 17

urine

Question 18

Toxin that causes mainly pulmonary signs which may be delayed by several days:

Answer 18

Paraquat

Question 19

These patients have greater oral absorption of lead and it crosses their BBB more easily:

Answer 19

young

Question 20

This toxin is 99% bound to RBCs in the bloodstream:

Answer 20

lead

Question 21

Bright red blood and mucous membranes are characteristic of this toxin:

Answer 21

cyanide

Question 22

Nitrite oxidizes ferrous iron on the heme group to ferric, resulting in __________

Answer 22

methemoglobin

Question 23

Deficiency of this predisposes to copper toxicity:

Answer 23

molybdenum

Question 24

Promotes the release of zinc which is why prolonged time in the stomach increases toxicity:

Answer 24

Acid

Question 25

North and South Dakota, Wyoming, Montana, Nebraska, Kansas, Utah, Colorado and New Mexico have soil __________ in selenium

Answer 25

**rich**

Question 26

This species is most susceptible to ionophore toxicity:

Answer 26

**horse**

Question 27

Sodium picrate paper exposed to cyanide from rumen contents will turn from yellow to __________ in a sealed container:

Answer 27

**brick red**

Question 28

This enters the brain by passive diffusion and is removed by active transport:

Answer 28

**sodium**

Question 29

Phenobarbital can be used to treat this toxin and may also enhance metabolism and excretion by inducing microsomal enzymes:

Answer 29

**metaldehyde**

Question 30

Arsenilic acid is used as a growth promoter in swine while *this* is used in poultry:

Answer 30

**roxarsone**

Question 31

Tiamulin, chloramphenicol, erythromycin and sulfonamides are examples of drugs that can increase toxicity of this:

Answer 31

**ionophore**

Question 32

Locoweed, aster and corn are plants that accumulates this mineral when the soil is rich in it:

Answer 32

**selenium**

Question 33

Very young animals (3-6wks) are __________ tolerant to dietary urea/NPN

Answer 33

**more**

Question 34

This toxin is bound to albumin and beta-2- macroglobulin in the blood:

Answer 34

**zinc**