Toxicology - Cannabinoids Flashcards
THC - Clinical Effects
mood elevation
euphoria
relaxation
creative thinking
increased sensory awareness
Marijuana Uses - Medical Conditions
anorexia
anxiety
asthma
depression
epilepsy
insomnia
migraine
MS
muscle spasms
NV
pain
Parkinson’s disease
Tourette syndrome
Phytocannabinoids - Clinical Effects (Wanted)
mood elevation
euphoria
relaxation
creative thinking
increased sensory awareness
appetite stimulation
nausea suppression
Phytocannabinoids - Clinical Effects (Paradoxical)
short-term memory difficulties
agitation
feeling tense
anxiety
dizziness
lightheadedness
confusion
loss of coordination
Cannabinoid Toxicity - Signs & Symptoms
CNS depression
disorientation
agitation
hallucinations
seizures
combativeness
anxiety
mydriasis
tachycardia
vomiting
Cannabinoid Toxicity - Lab Abnormalities
decreased potassium
increased blood glucose
increased creatinine kinase
increased creatinine
increased WBC
Cannabinoid-Induced Agitation - Management
lorazepam 2-4 mg
midazolam 5-10 mg
haloperidol 2.5-10 mg
droperidol 2.5-10 mg
olanzapine 5-10 mg
Cannabinoid-Induced Seizures - Management
lorazepam 2-4 mg
midazolam 5-10 mg
diazepam 5-10 mg
Cannabinoid-Induced Dehydration - Management
IV crystalloids
Cannabinoid-Induced Hypertension / Tachycardia - Management
benzodiazepines
IV antihypertensives as necessary
Cannabinoids Hyperemesis Syndrome
excessive vomiting due to chronic use
desensitization & downregulation of CB1 receptors that generally have antiemetic effects
CHS - Prodromal Phase
months to years
diffuse abdominal discomfort
agitation or stress
morning nausea, fear of vomiting
increased use of marijuana to treat
CHS - Hyperemetic Phase
24-48 hrs
cyclic episodes of NV
diffuse, severe abdominal pain
CHS - Recovery Phase
upon total cessation of cannabis
full resolution ~ 1 month
CHS - Management
hot showers
topical capsaicin
haloperidol / ondansetron
benzodiazepines
fluids & electrolytes
