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RU PA Pharm > Toxicology and Inflammation > Flashcards

Toxicology and Inflammation Flashcards

1
Q

fondaparinux

A

anticoag
has polysaccharide of heparin
binds ATIII and inhibitys Xa, but not thrombin

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2
Q

Protamine

A

basic drug used to reverse heparin, doesn’t work on fundaparinux, min effect on LMWH

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3
Q

Enoxaparin

A

LMWH

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4
Q

Dalteparin

A

LMWH

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5
Q

Tinzaparin

A

LMWH

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6
Q

Argatroban

A

direct thrombin inhibitor

IV

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7
Q

Bivalirudin

A

direct thrombin inhibitor

IV

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8
Q

Dabigatran

A

direct thrombin inhibitor

oral

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9
Q

Apixaban

A

Xa inhibitor

oral

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10
Q

Rivaroxaban

A

Xa inhibitor

oral

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11
Q

Kcentra

A

prothrombin protein concentrate

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12
Q

Streptokinase

A

fybronolytic

IV

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13
Q

alteplase

A

tPA

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14
Q

reteplase

A

tPA

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15
Q

tenecteplase

A

tPA

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16
Q

ticlopidine

A

antiplatelet

ADP antagonist

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17
Q

clopidogrel

A

antiplatelet

ADP antagonist

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18
Q

prasugrel

A

antiplatelet

ADP antagonist

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19
Q

ticagrelor

A

antiplatelet

ADP antagonist

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20
Q

cangrelor

A

antiplatelet

ADP antagonist

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21
Q

dipyridamole

A

antiplatelet

phosphodiasterase 3 inhibitor

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22
Q

abcximab

A

GP IIb/IIIa receptor inhibitors

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23
Q

aptifibatide

A

GP IIb/IIIa receptor inhibitors

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24
Q

tirfiban

A

GP IIb/IIIa receptor inhibitors

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25
insulin lispro
rapid insulin
26
insulin aspart
rapid insulin
27
insulin glulisine
rapid insulin
28
neutral protamine Hagedorn
intermediate insulin
29
insulin glargine
long insulin
30
insulin detemir
long insuline
31
afrezza
inhaled insulin
32
glyburide
secretagogue, sulfonylurea
33
glipizide
secretagogue, sulfonylurea
34
glimeperide
secretagogue, sulfonylurea
35
repaglinide
secretagogue, meglitinide, sulfar free
36
nateglinide
secretagogue,D-phenylnine , sulfar free
37
metformin
biguanide
38
pioglitazone
thiazolidinedione | PRAR-g
39
rosiglitazone
thiazolidinedione | PRAR-g
40
acarboze
a-glucosidise inhibitor
41
miglitol
a-glucosidise inhibitor
42
pramlintide
amylin analogue
43
exenatide
glucagon-polypeptide analogue, incretin
44
sitagliptin
DDP-4 enzyme inhibitor, which increases glucagon-polypeptide- incretin effect
45
cholestyramine
bile acid resin
46
colestipol
bile acid resin
47
ezetimibe
dietary cholestertol transport inhibitor
48
niacin
most effective for increasing HDL
49
clofibrate
fibric acid | most effective in lowering TG
50
gemfibrozil
fibric acid | most effective in lowering TG
51
alicorumab( Praluent)
monoclonal antibody PCSK9 inhibitor lowers LDL
52
dinoprostone
PGE2-vasodialator, GI mucosa protector | -induces labor, 2nd trimestor abortions
53
misoprostol
PGE1-vasodialator, GI mucosa protector, inhibits platelet aggregation used to tx gastric ulceration and NSADS gastric SE
54
alprostadil
PGE1-vasodialator, GI mucosa protector, inhibits platelet aggregation -improves blood flow in peripheral vascular disease, maintains PDA
55
latanoprost
PGF2-vaso and bronchoconstrictor | topical to control glaucoma
56
epoprostenol
PGI2-vasodialator, prevents and reverses platelet aggregation reverses pulmonary HTN
57
ibuprofen
COX non-selective NSAID | for inflammatory episode in gout
58
indomethacin
COX non-selective NSAID closes PDA not fr pain, only inflammation, 11%-headachefor inflammatory episode in gout
59
ketoprofen
COX non-selective NSAID
60
naproxen
COX non-selective NSAID
61
ketorolac
COX non-selective NSAID -recommended for pain only, not inflammation -renal failure headache 17%, dyspepsia, NV-12%
62
sulindac
COX non-selective NSAID | not for pain
63
rofecoxib
COX- 2 selective NSAID
64
celecoxib
COX- 2 selective NSAID
65
valdecoxib
COX- 2 selective NSAID
66
methotrexate
DMARD liver toxic not in pregnancy
67
leflunomide
DMARD | hepatotoxic, teratogenic
68
gold salts
DMARD
69
sulfasalazine
DMARD
70
hydroxychloroquine
DMARD
71
infliximab
anti-TNF RA and Crohn's used with methotrexate to reduce likelihood of antobody formation
72
adalimumab
anti-TNF | all human, so unlikely to have Ab response
73
etanercept
anti-TNF, decoy receptor
74
rituximab
anti-CD20 (antigen on B cells surface) | RA tx
75
anakinra
IL-1 receptor | RA tx
76
colchicine
anti-inflammatory, gout targets inflammatory cells directly acute tox:hemorrhagic gastroenteritis,vascular damage, nephrotoxic, acsending paralysis of CNS
77
probenecid
uricosuric, inhibits uric acid resorbtion in the proximal convoluted tubule, reduces its blood levels
78
allopurinol
xanthine oxadize inhibitor, reduces uric acid blood levels | chronic gout
79
febuxostat
xanthine oxadize inhibitor, reduces uric acid blood levels
80
hydrocortisone
glucocorticoid
81
cortisone
glucocorticoid, weaker than hydrocortisone
82
prednisone
glucocorticoid
83
methylprednisolone
glucocorticoid
84
triamcinolone
glucocorticoid
85
dexamethasone
glucocorticoid, 30x stronger than hydrocortisone
86
betamethasone
glucocorticoid, 25x stronger than hydrocortisone
87
aldosterone
mineralocorticoid
88
fludrocortisone
mineralocorticoid, 250x stronger than aldosteronr
89
aminoglutethimide
corticosteroid antagonist blocks steroid formation rate limiting step, conversion of cholesterol into pregnalone eliminates all hormonally active steroids
90
metyrapone
corticosteroid antagonist | inhibits cortisol synthesis, 11beta
91
trilostane
corticosteroid antagonist | 3beta dehydrogynase
92
cimetidine
h2 blocker
93
ranitidine
h2 blocker
94
famotidine
h2 blocker
95
nizatidine
h2 blocker
96
omeprazole
PPI
97
lansoprazole
PPI
98
rabeprazole
PPI
99
pantoprazole
PPI
100
esomeprazole
PPI
101
atropine
anti-muscarinic
102
glycopyrrolate
anti-muscarinic
103
misoprostol
protector from gastric acid | cytoprotective, for NSAIDS induces ulcer
104
sucralfate
protector from gastric acid | turns into pretective gel
105
metronidazole/tetracycline
antibiotic for ulcer H.pylori | use with bismuth sabsalycilate
106
clarythromyacin
antibiotic for ulcer,H.pylori | use with omeprazole
107
metoclopromide
pro-kinetic, increase ACh
108
cisapride
pro-kinetic, increase ACh
109
osmotic saline, PEG
osmotic laxative
110
docusate
surfactant laxative
111
psyllium
bulk forming laxative
112
bisacodyl
stimulat laxative
113
diphenoxylate
anti-diarrheal,opioid
114
loperamide
anti-diarrheal,opioid
115
bismuth sabsalycilate
anti-diarrheal,
116
ritanserin
serotonin 5Ht2 | antiplatelet
117
cyproheptadine
serotonin 5Ht2 | skin allergies
118
methysergide
serotonin 5Ht2 | migraine
119
ondansetron
serotonin 5Ht3 | anti emetic
120
diphenhydramine
H1, allergy cold
121
dimenhydrinate
H1, anti motion
122
meclizine
H1, anti motion
123
hydroxyzine
H1, anti motion
124
promethazine
H1, aallergy cold
125
chlorpheniramine
H1, aallergy cold
126
astemizole
H1, allergy
127
fexofenadine
H1, allergy
128
loratadine
H1, allergy
129
scopolamine
anti muscarinic,anti motion patch
130
prochlorperazine
D2 blocker, anti emetic on CTZ
131
chlorpromazine
D2 blocker, anti emetic on CTZ
132
metocloprmide
D2 blocker
133
promethazine
D2 blocker
134
chlorphenamine maleate
H1
135
azelastine
H1
136
cetirizine
zyrtec

RU PA Pharm (5 decks)

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