Toxicology

Question 1

Treatment of serotonin syndrome

Answer 1

1. Supportive measures
2. Benzodiazepines
3. Esmolol for hypertension and tachycardia
4. Sedation and intubation for temp more than 41.1
5. Cyproheptadine if agitation fails to improve with the above

Question 2

Treatment of NMS

Answer 2

1. Supportive care - fluids, cooling blankets, lower bp
2. Benzodiazepines for agitation
3. Dantrolene in moderate to severe cases and/or amantadine and bromocriptine
4. ECT - if not responding to medical therapy in the first week

Question 3

Indications for charcoal

Answer 3

Carbamazepine
Dapsone
Phenobarbitone
Theophylline

Question 4

Indications for urinary alkalanisation?

Answer 4

Phenobarbitone

Salicylates

Question 5

Indications for haemodialysis

Answer 5

Carbamazepine 
Lithium
Metformin 
Salicylates 
Valproate 
Alcohols

Question 6

What is the mechanism of organophosphate poisoning ?

Answer 6

Cholinesterase inhibitors causing cholinergic toxidrome