Medical Oncology Flashcards
Mechanism of palbociclib.
CDK4/6 inhibitor which inhibits transition from G1 to S phase of cell cycle
Which phase of the cell cycle do taxanes work?
M phase
In which phase does tamoxifen work?
G1
Dihydropyrimidine dehydrogenase deficiency predicts intolerance to which drug?
Fluorouracil and capecitabine
What is the treatment of extensive stage SCLC?
Chemotherapy
Prophylactic Cranial Irradiation
What is the treatment of limited stage SCLC?
Stage 1 (no nodes) - surgery and chemo
Stage 2 (nodes) - chemo and radiotherapy
Consider cranial irradiation if good response to treatment
In what testicular malignancy is AFP not raised?
Seminoma
Name some ALK inhibitors.
Crizotinib
Alectinib
Ceritinib
Name some PDL1 inhibitors
Durvalumab
Atezolizumab
Name some PD1 inhibitors
Nivolumab
Pembrolizumab
Do right sided CRC derive benefit from egfr inhibitors?
No
What is the first line therapy for BRAf positive metastatic melanoma?
Combination BRAF and MEK kinase inhibitor
What is the first line therapy for BRAF negative metastatic melanoma?
Combination ipilimumab and nivolumab if for
Single agent therapy with nivolumab or pembrolizumab if not fit
What are the two first line treatment options for clear cell renal cancer?
Sunitinib
Pazopanib
In what phase do the CDK 4/6 inhibitors work?
G1/S
