Haematology

Question 1

Best way to replace vWF?

Answer 1

Biostate

Question 2

What HB type is increased in alpha thalassemia?

Answer 2

HB Bart’s

Question 3

What HB type is increased in beta thalassemia?

Answer 3

HbA

Question 4

How does hydroxyurea work in sickle cell disease?

Answer 4

Increasing HBF

Question 5

What are the high risk cytogenetics of ALL?

Answer 5

Translocation 9:22
Translocation 4:11
Hypodiploidy

Question 6

What is the most common non Hodgkin lymphoma?

Answer 6

Diffuse large B cell lymphoma

Question 7

What is the benefit of azacitidine in MDS?

Answer 7

Delay in leukaemic transformation

Improved quality of life

Question 8

What are the indications for CLL treatment?

Answer 8

Marrow failure (cytopenia)
B symptoms 
Doubling time <6months
Massive nodes (>10cm)
Massive spleen (>6cm) 
Progressive symptomatic lymphadenopathy 
Uncontrolled autoimmune phenomena

Question 9

What does cryoprecipitate contain?

Answer 9

Fibrinogen
Factors 8 and 9
von Williebrand factor

Question 10

What does fresh frozen plasma contain? What is the INR or FFP

Answer 10

All coagulation factors

INR 1.6

Question 11

What does prothrombinex contain?

Answer 11

Factors 2, 9 and 10

Question 12

What does biostate contain?

When is it used?

Answer 12

Factor 8
von Williebrand factor

(Used in haemophilia A)

Question 13

What does FEIBA contain?

Answer 13

Activated factor 7

Factor 2, 7,9,10

Question 14

What is the best way to replace von Williebrand factor?

Answer 14

Biostate