Toxicology

Question 1

Paracetamol-MOA

Answer 1

Para Aminophenol derivative
Weak PG inhibitor
Cox3 antagonist action ‘Weak COx1 and 2 inhibitor

Question 2

Paracetamol- Pharmacokinetics

Answer 2

oral PR IV

Metabolized in liver via Glucoronidation + sulphation

Question 3

Aspirin-MOA

Answer 3

Irrevesible anti platelet action for the whole life of platelet
Irreversibly inhibits COX 1&2
Reduces PG Synthesis and Thromboxane A2 synthesis

Question 4

What happens to Aspirin in the Gut

Answer 4

Highly soluble in the stomach as itself a weak acid, rapidly absorbed
Less soluble in small intestine where it is absorbed mostly due to high surface area.

Question 5

Aspirin metabolism and excretion

Answer 5

In blood hydrolysed to acetic acid and salicylate by tissue estrase
Salicylate conjugated in liver to salyuric acid
Excreted by kidney firstly by first order kinetics then zero order kinetics.

Question 6

Aspirin Adverse effects

Answer 6

Bleeding 
peptic Ulceration
Asthma
Metabolic acidosis
renal failure
salisylism