Haemotology

Question 1

tPA- Mechanism of action

Answer 1

activates plasminogen bound to fibrin (hence ltd to thrombus) converts it(plasminogen) to plasmin which reduces fibrin to fibrin split products.

Question 2

How does tPA differs to Streptokinase

Answer 2

tPA naturally occurring human enyzyme
Streptokinase not an enzyme its a bacterial product which combines with plasminogen and catalyses conversion of further plasminogen to plasmin
prioir Strep infection can cause therapeutic resistance and allergic reaction due to preformed antibodies.

Question 3

Erythropoietin- Mech of Action

Answer 3

Glycoprotein form kidney that stimulates red cell precursors to differentiate and proliferate
Also stimulates marrow to release reticulocytes

Question 4

Erythropoietin- clinical use

Answer 4

Chronic anaemia form CRF.

Stimulates marrow in marrow failure states (aplastic anaemia, MPD, Cancer, AIDS)

Question 5

Erythropoietin- toxicity

Answer 5

Rapid HB rise- HTN, Thrombosis