Miscellaneous

Question 1

B Agoinist -MOA

Kinetics

Toxicity

pros and cons of different routes

Answer 1

Causes SM relaxation , bronchodilation, inhibit mast cell release, inc mucociliary transport
well absorbed all routes metabolised liver excreted kidney

Tachycardia, Palpitations
Hypokalemia
tremors

Inhaled- target organ delivery less systemic effect, expensive, noisy scares children, no benefit inn coordinated pt
Oral-easier in children longer t1/2, >sys toxicity
IV- >systemic effect and toxicity, no first pass metabolism
pain

Question 2

Factors affecting absorption from oral route

Answer 2

First pass metabolism
GI transit time
Gut Bacteria metabolism
Incomplete absorption

Question 3

Colchicine

Answer 3

Anti inflammatory effect

No effect on uric acid

Question 4

H1 blockers
Clinical use

Toxicity

Interaction

Answer 4

Allergy, urticaria
N&V
vestibular dysfunction
motion sickness

Sedation Seizures antimuscaranic effects

Additive effects with other sedatives and antimuscaranic drugs