Toxicities Flashcards

1
Q

Agents that DO NOT cause myelosuppression (3)

A

Asparginase
Bleomycin
Vincristine

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2
Q

Neuropathy (4)

A

Platinum Agents (cisplatin, etc)
Protease Inhibitors
Taxanes
Vinca Alkaloids

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3
Q

Cardiotoxicity

A

ANTHRACYCLINES
Breast Cancer drugs (trastuzumab, lapatinib)
CML TKIs (imatinib, nilotinib, dasatinib)

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4
Q

Pulmonary Toxicity (4)

A

Bleomycin
Methotrexate
Busulfan
Carmustine/Lomustine

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5
Q

Nephrotoxicity/Cystitis (Bladder Toxicity) (5)

A
Ifosfamide > Cyclophosphamide
*Mesna*
Arsenic
Bevacizumab
MTX
Platinum Agents 
(cisplatin *Amifostene*)
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6
Q

Acneiform Rash

A

EGFR Inhibitors

cetuximab, erlotinib, panitumumab, sorafenib, sunitinib

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7
Q

Mucositis (3)

A

5-FU / capecitabine
Irinotecan
MTX

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8
Q

Hand-foot Syndrome (5)

A
Capecitabine (Xeloda®)
Fluorouracil (5-FU®)
Doxorubicin (Adriamycin®)
Liposomal doxorubicin (Doxil®)
Cytarabine (Cytosar-U®)
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9
Q

Hand-foot Skin Reaction (9)

A
Sorafenib (Nexavar®)
Sunitinib (Sutent®)
Cabozantinib (Cometriq®)
Regorafenib (Stivarga®)
Axitinib (Inlyta®)
Pazopanib (Votrient®)
Vandetanib (Caprelsa®)
Vemurafenib (Zelboraf®)
Dabrafenib (Tafinlar®)
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10
Q

Alopecia (6)

A
TAXANES (paclitaxel, docetaxel)
ANTHRACYCLINES (doxorubicin, etc)
Ifosfamide / Cyclophosphamide
Carboplatin
Etoposide
Vinca Alkaloids (vincristine, etc)
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11
Q

Extravasation (Vesicants) (6)

A
Anthracyclines *DMSO or dexrazoxane
Vinca Alkaloids *Hyaluronidase + HEAT
Ixabepilone
Mitomycin
Etoposide *HEAT
Mechlorerhamine *sodium thiosulfate
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12
Q

Hepatotoxicity (7)

A
Folate + Pyrimidine Analogs (MTX)
Taxanes
Vinca Alkaloids
Busulfan
Aromatase Inhibitors / SERMS
Ixabepilone
some TKIs
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