Toxicities Flashcards
1
Q
Agents that DO NOT cause myelosuppression (3)
A
Asparginase
Bleomycin
Vincristine
2
Q
Neuropathy (4)
A
Platinum Agents (cisplatin, etc)
Protease Inhibitors
Taxanes
Vinca Alkaloids
3
Q
Cardiotoxicity
A
ANTHRACYCLINES
Breast Cancer drugs (trastuzumab, lapatinib)
CML TKIs (imatinib, nilotinib, dasatinib)
4
Q
Pulmonary Toxicity (4)
A
Bleomycin
Methotrexate
Busulfan
Carmustine/Lomustine
5
Q
Nephrotoxicity/Cystitis (Bladder Toxicity) (5)
A
Ifosfamide > Cyclophosphamide *Mesna* Arsenic Bevacizumab MTX Platinum Agents (cisplatin *Amifostene*)
6
Q
Acneiform Rash
A
EGFR Inhibitors
cetuximab, erlotinib, panitumumab, sorafenib, sunitinib
7
Q
Mucositis (3)
A
5-FU / capecitabine
Irinotecan
MTX
8
Q
Hand-foot Syndrome (5)
A
Capecitabine (Xeloda®) Fluorouracil (5-FU®) Doxorubicin (Adriamycin®) Liposomal doxorubicin (Doxil®) Cytarabine (Cytosar-U®)
9
Q
Hand-foot Skin Reaction (9)
A
Sorafenib (Nexavar®) Sunitinib (Sutent®) Cabozantinib (Cometriq®) Regorafenib (Stivarga®) Axitinib (Inlyta®) Pazopanib (Votrient®) Vandetanib (Caprelsa®) Vemurafenib (Zelboraf®) Dabrafenib (Tafinlar®)
10
Q
Alopecia (6)
A
TAXANES (paclitaxel, docetaxel) ANTHRACYCLINES (doxorubicin, etc) Ifosfamide / Cyclophosphamide Carboplatin Etoposide Vinca Alkaloids (vincristine, etc)
11
Q
Extravasation (Vesicants) (6)
A
Anthracyclines *DMSO or dexrazoxane Vinca Alkaloids *Hyaluronidase + HEAT Ixabepilone Mitomycin Etoposide *HEAT Mechlorerhamine *sodium thiosulfate
12
Q
Hepatotoxicity (7)
A
Folate + Pyrimidine Analogs (MTX) Taxanes Vinca Alkaloids Busulfan Aromatase Inhibitors / SERMS Ixabepilone some TKIs