Combination Chemo Regimens

Question 1

ABVD

Answer 1

Hodgkins Lymphoma

Doxorubicin 25 mg/m2
Bleomycin 10 mg/m2
Vinblastine 6mg/m2
Dacarbazine (DTIC) 375 mg/m2

Days 1 and 15 every 28 day cycle

Question 2

Tafasitamab-cxix + Lenalidomide

Answer 2

“Tafa-Len”
Monjuvi®

relapsed or refractory diffuse large B-cell lymphoma

Antibody-Drug Conjugate-CD19

Question 3

Loncastuximab tesirine

Answer 3

“Lonca-T”
ZYNLONTA®

relapsed or refractory diffuse large B-cell lymphoma

antibody-drug conjugate CD19

Question 4

FCR

Answer 4

Chronic Lymphocytic Leukemia (CLL)

Fludarabine: 25 mg/m2 IV days 1-3
Cyclophosphamide: 250 mg/m2 IV days 1-3
Rituximab*: 375 mg/m2 IV day 1

Cycle: 28 days

Question 5

R-CHOP

Answer 5

Non-Hodgkin Lymphomas (NHLs)

Cyclophosphamide 750 mg/m2 IV on day 1
Doxorubicin 50 mg/m2 IV on day 1
Vincristine 1.4 mg/m2 (maximum dose of 2mg per cycle) IV on day 1
Prednisone 100 mg PO QD on days 1-5
Rituximab 375 mg/m2 IV on day 1

Cycle: 21 days

Question 6

FLAG-IDA

Answer 6

AML Consolidation

-1 to 6 (7 days) G-CSF 5mcg/kg

1, 2,3,4,5, Fludarabine 30mg/m2

1,2,3,4,5, Cytarabine 2 g/m2

3, 4, and 5 Idarubicin 8mg/m2

Question 7

BEP

Answer 7

Testicular Germ Cell Tumors

Bleomycin 30 mg/m2
days 1, 8, and 15

Etoposide 100 mg/m2
Days 1-5

Cisplatin (Platinol) 20 mg/m2
Days 1-5

21 day cycle

Question 8

R-ICE

Answer 8

Lymphomas

Rituximab 375 mg/m2 (1,7,14)
Ifosfamide 2 g/m2 + Mesna (3,4,5)
Carboplatin AUC 5 (3,4,5)
Etoposide 75 mg/m2 (3,4,5)

Question 9

BEACOPP

Answer 9

Bleomycin 10 mg/m2
Etoposide 100 mg/m2
Doxorubicin 25 mg/m2
Cyclophosphamide 650 mg/m2
Vincristine 1.4 mg/m2
Procarbazine 100 mg/m2
Prednisone 40 mg/m2

Question 10

Teclistamab

Answer 10

TECVAYLI™ Janssen

BISPECIFIC B-cell maturation antigen (BCMA)-directed CD3 T-cell engager

R/R Multiple Myeloma after 4 prior lines of therapy

risk of CRS and neurologic toxicity, including ICANS

Question 11

Hyper CVAD

Answer 11

CycloPHOSphamide 300 mg/m2 IV over 3 hours every 12 hours for 6 doses on Days 1 – 3

DOXOrubicin 50 mg/m2 IV push or IV continuous infusion over 24 hours on Day 4

VinCRIStine 2 mg IV over 5 – 10 minutes on Days 4 and 11

DexAMETHasone 40 mg IV or PO daily on Days 1 – 4 and 11 – 14

21-day cycle for 4 cycles alternating with high-dose methotrexate/cytarabine:
Methotrexate 12 mg intrathecal Day 2
Cytarabine 100 mg intrathecal Day 7