toxic shock and skin scold comparison

Question 1

what was the study designed for?

Answer 1

This study was designed to compare the clinical characteristics, toxin expression,virulencefactors, and antimicrobial susceptibilities of staphylococci isolated from Taiwanese children with staphylococcal toxic shock syndrome (STSS) and staphylococcal scalded skin syndrome (SSSS).

Question 2

What was the method that they used to test for it?

Answer 2

Toxin- specific and virulence genes of the staphylococci were detected by polymerase chain reaction amplification.

Question 3

conclusions of the study?

Answer 3

The most distinguishing feature of these isolates is the greater frequency of pvl and seb carriage among those from the STSS group

. Most of the isolates were community-associated methicillin-resistant S. aureus that were highly resistant to macrolides but susceptible to trimethoprim-sulfamethoxazole.

Vancomycin remains the initial drug of choice for treatment of STSS and SSSS. More studies are needed to determine the efficacy of trimethoprim-sulfamethoxazole in children with these syndromes.

Question 4

(STSS)

(SSSS)

Answer 4

Staphylococcal toxic shock syndrome (STSS)

staphylococcal scalded skin syndrome (SSSS

Question 5

TSST-1?

Answer 5

TSST-1, the most common STSS toxin, is respon- sible for ∼75% of the STSS cases

Question 6

who was included in the study?

Answer 6

Children who had clinically defined STSS and SSSS between May 2001 and August2004were included in the study

Question 7

who had SSSS and STSS?

Answer 7

Sixteen children were identified as having either STSS ( ) or SSSS ( ) due to com- n p 6 n p 10 munity-associated S. aureus.

children with STSS were significantly older than children with SSSS

Question 8

bloodstream infections more common in which group?

Answer 8

STSS

Question 9

what did most children test positive for?

Answer 9

All 16 isolates tested positive for the fnbA gene, and a large percentage of isolates from both groups carried the etb gene

Question 10

toxins associated with STSS?

and whats speical about the SSSS toxins?

Answer 10

TSST-1 and enterotoxins are associated with STSS

In contrast, the exfoli- ative toxins are more closely associated with SSSS [14, 15]. These toxins behave as superantigens by releasing cytokines that stimulate T lymphocytes [24].

Question 11

primary action of FnbB?

Answer 11

The primary action of FnbB proteins is to bind to fibronectin in the extracellular matrix, thus facilitating the adhesion of S. aureus to the host cell