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CLINICAL CHEMISTRY REVIEW (NU) > TOXIC DRUG MONITORING > Flashcards

TOXIC DRUG MONITORING Flashcards

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1
Q

Pharmacodynamics

A

Study of what DRUGS DO to body

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2
Q

Pharmacokinetics

A

Studyof what BODY DOES to the drug

Biotransformation, Distribution, metabolism and elimination

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3
Q

First pass metabolism

A

drugs enter the hepatic route first before entering the general circulation
Hepatic route -> General circulation

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4
Q

Half-life

A

Time needed for drug’s concentration in serum to decrease into half

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5
Q

Peak specimen

A

Collection is done 30-60 mins after administration of drug

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6
Q

Trough specimen

A

collected before administration of succeeding dose

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7
Q

Classification of Drugs

Antibiotics

A
  • Aminoglycosides
  • Chloramphenicol
  • Vancomycin
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8
Q

Classification of Drugs

Anticonvulsants

A
  • Ethosuximide
  • Carbamazepine
  • Phenytoin
  • Phenobarbital
  • Valproic Acid
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9
Q

Antidepressants

A
  • Lithium
  • Fluoxetine
  • Tricyclic antidepressants
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10
Q

Anti-inflammatory/ Analgesics

A
  • Aspirin
  • Acetaminophen
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11
Q

Anti-neoplastic

A
  • Busulfan
  • Methotrexate
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12
Q

Bronchodilators

A

Theohylline

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13
Q

Cardioactive

A
  • Digoxin
  • Procainamide
  • Lidocaine
  • Propanolol
  • Quinidine
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14
Q

Immunnosuppressives

A
  • Tacrolimus (FK-506)
  • Prednisone
  • Cyclosporine
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15
Q

Aspirin

A

drug that inhibits cyclooxygenase

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16
Q

Acetaminophen

A

Hepatotoxic drug

17
Q

Lithium

A

Treatment for bipolar disorder or manic depression

18
Q

Phenobarbital

A

Treatment of granmal

19
Q

Valproic acid

A

Treatment of petit mal

20
Q

Vancomycin

A

Cause of red man syndrome

21
Q

What are the analyte and conversion factor with this units?

g/dL to g/L

Conventional unit to SI unit

A
  • Albumin and Total Protein (10)
  • Phospholipid (0.01)

Analyte and Conversion Factor

22
Q

What are the analyte and conversion factor with this units?

μg/dL to μmol/L

Conventional unit to SI unit

A

Ammonia (0.587)

Analyte and Conversion Factor

23
Q

What are the analyte and conversion factor with this units?

μg/dL to nmol/L

Conventional unit to SI unit

A

Thyroxine (12.9)

Analyte and Conversion Factor

24
Q

What are the analyte and conversion factor with this units?

mEq/L to mmol/L

Conventional unit to SI unit

A
  • Bicarbonate, Chloride, Potassium, Sodium (1.0)
  • Magnesium (0.5)

Analyte and Conversion Factor

25
Q

What are the analyte and conversion factor with this units?

mEq/L to μmol/L

Conventional unit to SI unit

A

Lithium (1.0)

Analyte and Conversion Factor

26
Q

What are the analyte and conversion factor with this units?

mg/dL to mmol/L

Conventional unit to SI unit

A
  • Bun (0.357)
  • Calcium (0.25)
  • Cholesterol (0.026)
  • Glucose (0.0555)
  • Phosphorus (0.323)
  • Triglyceride (0.0113)
  • Uric acid (0.0595)

Analyte and Conversion Factor

27
Q

What are the analyte and conversion factor with this units?

mg/dL to μmol/L

Conventional unit to SI unit

A
  • Bilirubin (17.1)
  • Creatinine (88.4)
  • Iron (0.179)

Analyte and Conversion Factor

28
Q

What are the analyte and conversion factor with this units?

mmHg to kPa

Conventional unit to SI unit

A
  • pCO2 and pO2 (0.133)

Analyte and Conversion Factor

CLINICAL CHEMISTRY REVIEW (NU) (4 decks)

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