TOXIC DRUG MONITORING Flashcards
Pharmacodynamics
Study of what DRUGS DO to body
Pharmacokinetics
Studyof what BODY DOES to the drug
Biotransformation, Distribution, metabolism and elimination
First pass metabolism
drugs enter the hepatic route first before entering the general circulation
Hepatic route -> General circulation
Half-life
Time needed for drug’s concentration in serum to decrease into half
Peak specimen
Collection is done 30-60 mins after administration of drug
Trough specimen
collected before administration of succeeding dose
Classification of Drugs
Antibiotics
- Aminoglycosides
- Chloramphenicol
- Vancomycin
Classification of Drugs
Anticonvulsants
- Ethosuximide
- Carbamazepine
- Phenytoin
- Phenobarbital
- Valproic Acid
Antidepressants
- Lithium
- Fluoxetine
- Tricyclic antidepressants
Anti-inflammatory/ Analgesics
- Aspirin
- Acetaminophen
Anti-neoplastic
- Busulfan
- Methotrexate
Bronchodilators
Theohylline
Cardioactive
- Digoxin
- Procainamide
- Lidocaine
- Propanolol
- Quinidine
Immunnosuppressives
- Tacrolimus (FK-506)
- Prednisone
- Cyclosporine
Aspirin
drug that inhibits cyclooxygenase
Acetaminophen
Hepatotoxic drug
Lithium
Treatment for bipolar disorder or manic depression
Phenobarbital
Treatment of granmal
Valproic acid
Treatment of petit mal
Vancomycin
Cause of red man syndrome
What are the analyte and conversion factor with this units?
g/dL to g/L
Conventional unit to SI unit
- Albumin and Total Protein (10)
- Phospholipid (0.01)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
μg/dL to μmol/L
Conventional unit to SI unit
Ammonia (0.587)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
μg/dL to nmol/L
Conventional unit to SI unit
Thyroxine (12.9)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
mEq/L to mmol/L
Conventional unit to SI unit
- Bicarbonate, Chloride, Potassium, Sodium (1.0)
- Magnesium (0.5)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
mEq/L to μmol/L
Conventional unit to SI unit
Lithium (1.0)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
mg/dL to mmol/L
Conventional unit to SI unit
- Bun (0.357)
- Calcium (0.25)
- Cholesterol (0.026)
- Glucose (0.0555)
- Phosphorus (0.323)
- Triglyceride (0.0113)
- Uric acid (0.0595)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
mg/dL to μmol/L
Conventional unit to SI unit
- Bilirubin (17.1)
- Creatinine (88.4)
- Iron (0.179)
Analyte and Conversion Factor
What are the analyte and conversion factor with this units?
mmHg to kPa
Conventional unit to SI unit
- pCO2 and pO2 (0.133)
Analyte and Conversion Factor
