Tox: NSAIDs

Question 1

Most common NSAID in overdose

Answer 1

ibuprofen

Question 2

MOA of NSAIDs

Answer 2

inhibit COX to reduce PG production. PGs have roles in mediating pain/inflammation, maintaining gastric mucosa, regulating blood flow to kidneys.

Question 3

Mxn of NSAID toxicity

Answer 3

GI: n/v, gastritis, UGIB
Renal: ARF due to reduced blood flow (more common in chronic toxicity).
Metabolic: AGMA (2* NSAID or metabolite)
Systemic: if massive OD, cerebral and pulmonary edema, seizures, coma.

Question 4

Ibuprofen dose that causes toxicity

Answer 4

> 200mg/kg

Question 5

Symptoms in NSAID OD

Answer 5

Abdo pain, n/v, renal insufficiency.
AMS< seizure, AGMA if severe ingestion.
Ibuprofen specifically causes cerebral, pulmonary edema, seizures, coma.

Question 6

Tx NSAID OD

Answer 6

Supportive only